1,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-6-phenyl-3-(1-pyrrolidinyl)-

Base Information

Chemical Name:1,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-6-phenyl-3-(1-pyrrolidinyl)-
CAS No.:87540-77-0
Molecular Formula:C₁₉H₁₆ClN₅
Molecular Weight:349.823
Hs Code.:
DSSTox Substance ID:DTXSID40236442
Wikidata:Q83118408

Synonyms:1,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-6-phenyl-3-(1-pyrrolidinyl)-;87540-77-0;8-Chloro-6-phenyl-3-(1-pyrrolidinyl)-1,2,4-triazolo(3,4-a)phthalazine;C19H16ClN5;SCHEMBL10664826;C19-H16-Cl-N5;DTXSID40236442;LS-156580

Suppliers and Price of 1,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-6-phenyl-3-(1-pyrrolidinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-6-phenyl-3-(1-pyrrolidinyl)-

Chemical Property:

PSA：46.32000
Density:1.45g/cm³
LogP:4.26310
XLogP3:4.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:349.1094232
Heavy Atom Count:25
Complexity:465

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)C2=NN=C3N2N=C(C4=C3C=CC(=C4)Cl)C5=CC=CC=C5

Technology Process of 1,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-6-phenyl-3-(1-pyrrolidinyl)-

There total 6 articles about 1,2,4-Triazolo(3,4-a)phthalazine, 8-chloro-6-phenyl-3-(1-pyrrolidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 123-75-1
pyrrolidine

: 87540-75-8
3,8-dichloro-6-phenyl-1,2,4-triazolo[3,4-a]phthalazine

: 87540-77-0
8-Chloro-6-phenyl-3-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine

Guidance literature:

Reference yield:

: 33184-56-4
2-benzoyl-4-chlorobenzoic acid

: 87540-77-0
8-Chloro-6-phenyl-3-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine

Guidance literature:: Multi-step reaction with 6 steps

1: 76 percent / hydrazine hydrate / ethanol / 1 h / Heating

2: 1.) phosphorus oxychloride; 2.) conc. ammonium hydroxide / 1.) 1 h, 100 degC; 2.) 20 degC, pH=7.8; 10 min

3: 92 percent / hydrazine hydrate / ethanol / 2 h / Heating

4: 88 percent / potassium hydroxide / H₂O; ethanol / Heating

5: 55 percent / chlorine / CHCl₃; H₂O / 4 h / 0 °C

6: 82 percent

With potassium hydroxide; ammonium hydroxide; chlorine; hydrazine hydrate; trichlorophosphate; In ethanol; chloroform; water;

Reference yield:

: 120116-65-6
6-chloro-4-phenylphthalazine-1(2H)-one

: 87540-77-0
8-Chloro-6-phenyl-3-pyrrolidin-1-yl-[1,2,4]triazolo[3,4-a]phthalazine

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) phosphorus oxychloride; 2.) conc. ammonium hydroxide / 1.) 1 h, 100 degC; 2.) 20 degC, pH=7.8; 10 min

2: 92 percent / hydrazine hydrate / ethanol / 2 h / Heating

3: 88 percent / potassium hydroxide / H₂O; ethanol / Heating

4: 55 percent / chlorine / CHCl₃; H₂O / 4 h / 0 °C

5: 82 percent

With potassium hydroxide; ammonium hydroxide; chlorine; hydrazine hydrate; trichlorophosphate; In ethanol; chloroform; water;