33184-56-4

Basic information

• Product Name: 2-Benzoyl-4-chlorobenzoic acid
• Synonyms: 2-Benzoyl-4-chlorobenzoic acid
• CAS NO: 33184-56-4
• Molecular Formula: C₁₄H₉ClO₃
• Molecular Weight: 260.67
• Mol File: 33184-56-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Benzoyl-4-chlorobenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Benzoyl-4-chlorobenzoic acid(33184-56-4)
• EPA Substance Registry System: 2-Benzoyl-4-chlorobenzoic acid(33184-56-4)

Safety Data

• Hazardous Substances Data: 33184-56-4(Hazardous Substances Data)

Upstream product

• 57892-55-4 2-benzoyl-4-chlorobenzonitrile 
• 118-45-6 4-chlorophthalic anhydride 
• 71-43-2 benzene 
• 25563-14-8 4-chloro-N-methoxybenzamide 
• 100-52-7 benzaldehyde 
• 74-11-3 para-chlorobenzoic acid 
• 122-01-0 4-chloro-benzoyl chloride 
• 611-73-4 Benzoylformic acid 
• 7446-70-0 aluminium trichloride 
• 33184-55-3 5-chloro-2-methyl-benzophenone 
• 7499-06-1 5-chloro-2-methylbenzoic acid 

Downstream Products

• 131-09-9 2-chloroanthracene-9,10-dione 
• 143915-48-4 8-Chloro-9b-phenyl-2,3-dihydro-9bH-thiazolo[2,3-a]isoindol-5-one 
• 52200-28-9 5-Chloro-2-hydroxymethyl benzhydrol 
• 844872-60-2 2-benzoyl-4-chloro-benzoyl chloride 
• 1332697-13-8 6-chloro-1-oxo-4-phenyl-2-propyl-1,2-dihydroisoquinoline-3-carboxylic acid 
• 1332697-14-9 2-butyl-6-chloro-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic acid 

Relevant articles and documents

Synthesis of biaryl imino/keto carboxylic acids via aryl amide directed C-H activation reaction

A novel Pd-catalysed C-H activation reaction for the synthesis of biaryl imino/keto carboxylic acids is developed. This reaction underwent aryl amide directed C-H activation ortho-acylation followed by ring closing and ring opening processes to give a range of biaryl imino/keto carboxylic acids. Our methodology features the utilization of a cheap and green oxidant (TBHP) as well as readily available aldehydes.

2-Hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic Acid with Inbuilt β-NHydroxy-γ-keto-Acid pharmacophore as HCV NS5B polymerase inhibitors

The inbuilt 2-N-hydroxy-1-oxo-3-carboxylic acid of isoquinolone was designed as pyrophosphate mimic for hepatitis C NS5B polymerase. Various 2-hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid derivatives 11a-p were synthesized and evaluated as HCV NS5B polymerase inhibitors. Compound 11c exhibited moderate inhibitory potency based on the inorganic pyrophosphate generation (IC50 = 9.5 μM) and based on NTP incorporation by NS5B enzyme (IC50 = 5.9 μM). Compound 11c demonstrated antiviral activity (EC50 = 15.7 μM) and good selectivity in HCV genotype 1b replicon Ava.5 cells. Compound 11c reduced the interaction of NTP to NS5B polymerase. Docking model showed that 11c situated in similar orientation to the bound uridine triphosphate in the active site of NS5B polymerase. As a result, 2-hydroxy-1-oxo-1,2-dihydroisoquinoline-3-carboxylic acid was disclosed as a novel inbuilt β-Nhydroxy-γ-keto-acid pharmacophore for HCV NS5B polymerase inhibitors.

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)

A novel series of 4-phenylisoquinolones were synthesized and evaluated as c-Jun N-terminal kinase (JNK) inhibitors. Initial modification at the 2- and 3-positions of the isoquinolone ring of hit compound 4, identified from high-throughput screening, led to the lead compound 6b. The optimization was carried out using a JNK1-binding model of 6b and several compounds exhibited potent JNK inhibition. Among them, 11g significantly inhibited cardiac hypertrophy in rat pressure-overload models without affecting blood pressure and the concept of JNK inhibitors as novel therapeutic agents for heart failure was confirmed.