1H-1,4-Benzodiazepine-1-propanenitrile, 3-[[1-(2-cyanoethyl)-1H-indol-3-yl]methyl]-5-(2-fluorophenyl)-2,3-dihydro- 2-oxo-, (R)-

Base Information

Chemical Name:1H-1,4-Benzodiazepine-1-propanenitrile, 3-[[1-(2-cyanoethyl)-1H-indol-3-yl]methyl]-5-(2-fluorophenyl)-2,3-dihydro- 2-oxo-, (R)-
CAS No.:103343-82-4
Molecular Formula:C₃₀H₂₄FN₅O
Molecular Weight:489.552
Hs Code.:
Mol file:103343-82-4.mol

Synonyms:

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Chemical Property of 1H-1,4-Benzodiazepine-1-propanenitrile, 3-[[1-(2-cyanoethyl)-1H-indol-3-yl]methyl]-5-(2-fluorophenyl)-2,3-dihydro- 2-oxo-, (R)-

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-1,4-Benzodiazepine-1-propanenitrile, 3-[[1-(2-cyanoethyl)-1H-indol-3-yl]methyl]-5-(2-fluorophenyl)-2,3-dihydro- 2-oxo-, (R)-

There total 4 articles about 1H-1,4-Benzodiazepine-1-propanenitrile, 3-[[1-(2-cyanoethyl)-1H-indol-3-yl]methyl]-5-(2-fluorophenyl)-2,3-dihydro- 2-oxo-, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1581-13-1
2-amino-2'-fluorobenzophenone

: 103343-82-4
3-[(R)-3-[1-(2-Cyano-ethyl)-1H-indol-3-ylmethyl]-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / 0 °C

2: aq. NaOH / methanol / 72 h

3: 1.) NaH / 1.) DMF, 0 deg C, 40 min, 2.) DMF, from 0 deg C to RT, 20 min

With sodium hydroxide; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1021/jm00390a019

Reference yield:

: 103222-66-8
D-tryptophan acid chloride hydrochloride

: 103343-82-4
3-[(R)-3-[1-(2-Cyano-ethyl)-1H-indol-3-ylmethyl]-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / 0 °C

2: aq. NaOH / methanol / 72 h

3: 1.) NaH / 1.) DMF, 0 deg C, 40 min, 2.) DMF, from 0 deg C to RT, 20 min

With sodium hydroxide; sodium hydride; In tetrahydrofuran; methanol;
DOI:10.1021/jm00390a019

Reference yield:

: 103342-80-9
2-N-(D-tryptophanyl)amino-2'-fluorobenzophenonehydrochloride

: 103343-82-4
3-[(R)-3-[1-(2-Cyano-ethyl)-1H-indol-3-ylmethyl]-5-(2-fluoro-phenyl)-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl]-propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: aq. NaOH / methanol / 72 h

2: 1.) NaH / 1.) DMF, 0 deg C, 40 min, 2.) DMF, from 0 deg C to RT, 20 min

With sodium hydroxide; sodium hydride; In methanol;
DOI:10.1021/jm00390a019