5-chloro-4-[1H-imidazol-1-yl(diphenyl)methyl]-2-pyrimidinyl methyl sulfide

Base Information

Chemical Name:5-chloro-4-[1H-imidazol-1-yl(diphenyl)methyl]-2-pyrimidinyl methyl sulfide
CAS No.:74840-37-2
Molecular Formula:C₂₁H₁₇ClN₄S
Molecular Weight:392.912
Hs Code.:
DSSTox Substance ID:DTXSID301159645

Synonyms:DTXSID301159645;AKOS024422549;5-Chloro-4-(1H-imidazol-1-yldiphenylmethyl)-2-(methylthio)pyrimidine;5-chloro-4-[1H-imidazol-1-yl(diphenyl)methyl]-2-pyrimidinyl methyl sulfide;74840-37-2

Suppliers and Price of 5-chloro-4-[1H-imidazol-1-yl(diphenyl)methyl]-2-pyrimidinyl methyl sulfide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-chloro-4-[1H-imidazol-1-yl(diphenyl)methyl]-2-pyrimidinyl methyl sulfide

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:392.0862454
Heavy Atom Count:27
Complexity:449

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CSC1=NC=C(C(=N1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=CN=C4)Cl

Technology Process of 5-chloro-4-[1H-imidazol-1-yl(diphenyl)methyl]-2-pyrimidinyl methyl sulfide

There total 4 articles about 5-chloro-4-[1H-imidazol-1-yl(diphenyl)methyl]-2-pyrimidinyl methyl sulfide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 74840-36-1
α-(5-chloro-2-methylthio-4-pyrimidinyl)benzhydrol

: 3005-50-3
N,N'-Thionyldiimidazole

: 74840-37-2
(5-chloro-2-methylthio-4-pyrimidinyl)-diphenyl-(1-imidazolyl)methane

Guidance literature:: In acetonitrile; for 48h;
DOI:10.1135/cccc19800539

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 74840-37-2
(5-chloro-2-methylthio-4-pyrimidinyl)-diphenyl-(1-imidazolyl)methane

Guidance literature:: Multi-step reaction with 2 steps

1: 1) Mg / 1) diethylether; 2) diethyl ether, 30 deg C, 1.5 h

2: 51 percent / acetonitrile / 48 h

With magnesium; In acetonitrile;
DOI:10.1135/cccc19800539

Reference yield:

: 61727-33-1
5-chloro-2-(methylthio)pyrimidine-4-carboxylic acid

: 74840-37-2
(5-chloro-2-methylthio-4-pyrimidinyl)-diphenyl-(1-imidazolyl)methane

Guidance literature:: Multi-step reaction with 3 steps

1: 68.6 percent / HCl(g) / 1 h / 60 - 70 °C

2: 1) Mg / 1) diethylether; 2) diethyl ether, 30 deg C, 1.5 h

3: 51 percent / acetonitrile / 48 h

With hydrogenchloride; magnesium; In acetonitrile;
DOI:10.1135/cccc19800539