methyl cis-2-(2-oxopropyl)cyclohexane-1-carboxylate

Base Information

• Chemical Name: methyl cis-2-(2-oxopropyl)cyclohexane-1-carboxylate
• CAS No.: 58706-96-0
• Molecular Formula: C₁₁H₁₈O₃
• Molecular Weight: 198.262
• Mol file: 58706-96-0.mol

Synonyms:

Chemical Property of methyl cis-2-(2-oxopropyl)cyclohexane-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl cis-2-(2-oxopropyl)cyclohexane-1-carboxylate

There total 18 articles about methyl cis-2-(2-oxopropyl)cyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-(methoxycarbonyl)phenyl)acetic acid (14736-49-3) → methyl cis-2-(2-oxopropyl)cyclohexane-1-carboxylate (58706-96-0,125258-90-4,128572-44-1,128572-45-2,135028-31-8,135028-36-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 5.5 g / H₂ / Pt₂O / acetic acid; H₂O / 48 h / 2758.2 Torr / Ambient temperature

2: oxalyl chloride / benzene / Ambient temperature

3: 1.57 g / diethyl ether / Ambient temperature

With oxalyl dichloride; hydrogen; Adam’s catalyst; In diethyl ether; water; acetic acid; benzene;

Reference yield:

(+/-)-(1RS,2RS)-2-(methoxycarbonyl)cyclohexane acetic acid (125258-89-1) → methyl cis-2-(2-oxopropyl)cyclohexane-1-carboxylate (58706-96-0,125258-90-4,128572-44-1,128572-45-2,135028-31-8,135028-36-3)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / benzene / Ambient temperature

2: 1.57 g / diethyl ether / Ambient temperature

With oxalyl dichloride; In diethyl ether; benzene;

Reference yield:

t-butyl 2-acetyl-5-octenoate (128488-46-0) → (1S,2R)-2-(2-Oxo-propyl)-cyclohexanecarboxylic acid methyl ester (58706-96-0,125258-90-4,128572-44-1,128572-45-2,135028-31-8,135028-36-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 45 percent / conc. H₂SO₄ / acetic anhydride / a) below -10 deg C, 10 min, b) r.t., 4h

2: 70 percent / acetonitrile; acetone / 2.5 h / Irradiation

3: H₂O / Heating

With sulfuric acid; water; In acetic anhydride; acetone; acetonitrile;

upstream raw materials:

diazomethane

t-butyl 2-acetyl-5-octenoate

3-(5-hexenyl)-2-methyl-4-oxo-1,5-dioxaspiro<5.5>undec-2-ene

6-Bromo-1-hexene

Downstream raw materials:

(1S,2S)-2-((R)-2-Hydroxy-propyl)-cyclohexanecarboxylic acid hydrazide

Refernces

• 1、 Sato, Masayuki,Abe, Yoshito,Kaneko, Chikara. "Synthesis of 1,3-dioxin-4-ones and their use in synthesis. 21. Intramolecular photocycloaddition reactions of chiral spirocyclic dioxinones having ω-alkenyl groups at 3-position". . p. 217 - 221. Retrieved 2007/10/02.