14736-49-3

Basic information

• Product Name: 2-[2-(Methoxycarbonyl)phenyl]acetic acid
• Synonyms: 2-[2-(Methoxycarbonyl)phenyl]acetic acid
• CAS NO: 14736-49-3
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Mol File: 14736-49-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-[2-(Methoxycarbonyl)phenyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(Methoxycarbonyl)phenyl]acetic acid(14736-49-3)
• EPA Substance Registry System: 2-[2-(Methoxycarbonyl)phenyl]acetic acid(14736-49-3)

Safety Data

• Hazardous Substances Data: 14736-49-3(Hazardous Substances Data)

Usage

General Description

2-[2-(Methoxycarbonyl)phenyl]acetic acid, also known as phenacemide, is a chemical compound with the molecular formula C11H12O4. It is a carboxylic acid derivative that is commonly used as an analgesic and antipyretic medication. Phenacemide works by inhibiting the synthesis of prostaglandins, which are involved in mediating pain and inflammation. It is also thought to act on the central nervous system to help alleviate pain. 2-[2-(Methoxycarbonyl)phenyl]acetic acid is commonly used in the treatment of headaches, migraines, and various types of pain. It is available in various formulations, including tablets and capsules, and is typically administered orally. However, the use of phenacemide has declined in recent years due to safety concerns, such as potential liver toxicity, and it is no longer widely used in many countries.

Upstream product

• 186581-53-3 diazomethane 
• 89-51-0 Homophthalic acid 
• 124-38-9 carbon dioxide 
• 41150-46-3 methyl 2-hydroxymethylbenzoate 
• 95-13-6 1-indene 
• 74-88-4 methyl iodide 
• 716-43-8 dimethyl homophthalate 
• 76-05-1 trifluoroacetic acid 
• 4090-69-1 3-methoxy-1H-isochromen-1-one 

Downstream Products

• 102172-03-2 1-(2-Carboxy-phenyl)-6-phenoxy-hexanon-⁽²⁾ 
• 125258-98-2 (1S,2S)-2-((R)-2-Hydroxy-propyl)-cyclohexanecarboxylic acid hydrazide 
• 125259-02-1 (1S,2S)-2-Chlorocarbonylmethyl-cyclohexanecarboxylic acid methyl ester 
• 58706-96-0 methyl cis-2-(2-oxopropyl)cyclohexane-1-carboxylate 
• 104815-78-3 2-(3-Acetoxy-2-oxo-propyl)-benzoic acid methyl ester 
• 23362-56-3 Homophthalsaeuremonoamid-(1) 
• 89462-33-9 2-malonamoylphenylacetic acid 
• 104815-77-2 methyl 2-(3-diazo-2-oxopropyl)benzoate 
• 40570-26-1 methyl 2-(2-chloro-2-oxoethyl)benzoate 
• 125258-89-1 (+/-)-(1RS,2RS)-2-(methoxycarbonyl)cyclohexane acetic acid 
• 1355049-08-9 methyl 2-{[(anilinocarbonyl)amino]methyl}benzoate 
• 1355049-05-6 methyl 2-{[(methoxycarbonyl)amino]methyl}benzoate 
• 1355049-02-3 methyl 2-(2-azido-2-oxoethyl)benzoate 
• 83901-96-6 methyl 2-<2-<<1-<2-(1-piperidinyl)phenyl>ethyl>amino>-2-oxoethyl>-benzoate 

Relevant articles and documents

Electrochemical direct carboxylation of benzyl alcohols having an electron-withdrawing group on the phenyl ring: One-step formation of phenylacetic acids from benzyl alcohols under mild conditions

Electrochemical direct carboxylation of benzyl alcohols having an electron-withdrawing group on the phenyl ring was successfully carried out by constant current electrolysis using an undivided cell equipped with a platinum plate cathode and a magnesium rod anode in DMF in the presence of carbon dioxide. Reductive cleavage of the C-O bond followed by fixation of carbon dioxide efficiently took place at the benzylic position without any additive to give the corresponding phenylacetic acids in good yields in one step under neutral and mild conditions.

New approaches to the synthesis of spiro-peroxylactones

Ozonolysis of (alkenyldioxy)cyclododecyl hydroperoxides in trifluoroethanol gave a separable mixture of the corresponding a-hydroperoxy- and a-hydroxy-substituted spiro-tetraoxacycloalkanes with ring sizes in the range 7-12. Dehydration of the hydroperoxides or oxidation of the hydroxy-compounds afforded the corresponding peroxylactones. The solid-state structure of 1,2,6,7-tetraoxaspiro[7.11]nonadecan-3-one was determined by X-ray crystallographic analysis.

Use of Phosphorus Pentoxide. Preparation of Half-esters through Selective Esterification

Methyl 2-,3-,4-carboxyphenylacetate and methyl 2-,3-,4-carboxyphenoxyacetate have been prepared through selective esterification of the aliphatic carboxylic acid function of the corresponding dicarboxylic acids using a mixture of phosphorus pentoxide (1 part), anhydrous copper sulphate (5 parts) and anhydrous sodium sulphate (5 parts).All the isomeric half-esters have been prepared through partial hydrolysis of the corresponding dimethylesters.