N-(2-aminophenyl)-4-methoxybenzamide

Base Information

• Chemical Name: N-(2-aminophenyl)-4-methoxybenzamide
• CAS No.: 103517-57-3
• Molecular Formula: C14H14N2O2
• Molecular Weight: 242.277
• UNII: N26VF3Q659
• DSSTox Substance ID: DTXSID801289728
• Pharos Ligand ID: VDJFGSM4DFC9
• ChEMBL ID: CHEMBL236061
• Mol file: 103517-57-3.mol

Synonyms:N-(2-aminophenyl)-4-methoxybenzamide;103517-57-3;N26VF3Q659;N-(2-Aminophenyl)-4-methoxy-benzamide;Benzamide, N-(2-aminophenyl)-4-methoxy-;D0YO6M;Cambridge id 5129152;Oprea1_722128;benzamide-type inhibitor, 22;UNII-N26VF3Q659;CHEMBL236061;SCHEMBL5226034;BDBM19426;DTXSID801289728;STK156256;AKOS000130378;N-(2-Amino-phenyl)4-methoxy-benzamide;N-(2-amino-phenyl)-4-methoxy-benzamide;NCGC00240897-01;N1-(4-methoxybenzoyl)-1,2-benzenediamine;N1-(4-methoxy-benzoyl)-1,2-benzenediamine;SR-01000196394;SR-01000196394-1

Chemical Property of N-(2-aminophenyl)-4-methoxybenzamide

Chemical Property:

• PSA: 64.35000
• LogP: 3.18390
• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 242.105527694
• Heavy Atom Count: 18
• Complexity: 275

Purity/Quality:

N-(2-AMINOPHENYL)-4-METHOXYBENZAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)NC2=CC=CC=C2N

Technology Process of N-(2-aminophenyl)-4-methoxybenzamide

There total 11 articles about N-(2-aminophenyl)-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxyl-N-(2-nitrophenyl)benzamide (7464-50-8) → N1-(4-methoxybenzoyl)-1,2-benzenediamine (103517-57-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 15h;

DOI:10.1016/j.bmc.2004.11.005

Reference yield: 96.0%

phenyl 4-methoxybenzoate (4181-97-9) + 1,2-diamino-benzene (95-54-5) → N1-(4-methoxybenzoyl)-1,2-benzenediamine (103517-57-3)

Guidance literature:

With C₄₆H₅₂Cl₃N₃O₂Pd; potassium carbonate; In water monomer; toluene; at 110 ℃; for 16h; Sealed tube;

DOI:10.1039/d1ob02051j

Reference yield: 88.0%

N-(2-iodophenyl)-4-methoxybenzamide (329939-01-7) → N1-(4-methoxybenzoyl)-1,2-benzenediamine (103517-57-3)

Guidance literature:

With ammonium hydroxide; potassium phosphate; copper(II) bis(trifluoromethanesulfonate); vasicine; In ethanol; at 70 ℃; for 12h; regioselective reaction; Sealed tube;

DOI:10.1016/j.tetlet.2021.153001

upstream raw materials:

4-methoxyl-N-(2-nitrophenyl)benzamide

4-methoxybenzoic acid

1,2-diamino-benzene

4-methoxy-benzoyl chloride

Downstream raw materials:

N¹-(3-cyanobenzoyl)-N²-(4-methoxybenzoyl)-1,2-benzenediamine

N¹-(4-cyanobenzoyl)-N²-(4-methoxybenzoyl)-1,2-benzenediamine

N₁-(3-Bromo-4-fluorobenzoyl)-N₂-(4-methoxybenzoyl)-1,2-benzenediamine

1-(4-methoxybenzoyl)-1H-1,2,3-benzotriazole