(-)-(2S,5S,6S,8S,9S,11S)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol

Base Information

• Chemical Name: (-)-(2S,5S,6S,8S,9S,11S)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol
• CAS No.: 115030-96-1
• Molecular Formula: C₄₁H₅₀O₆SSi
• Molecular Weight: 698.996

Synonyms:

Chemical Property of (-)-(2S,5S,6S,8S,9S,11S)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(2S,5S,6S,8S,9S,11S)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol

There total 37 articles about (-)-(2S,5S,6S,8S,9S,11S)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

benzaldehyde (100-52-7) + (+)-<1S(1S),3S,4S,6S>-6-<(tert-butyldiphenylsilyloxy)methyl>-1-<1-(hydroxymethyl)-3-(phenylsulphonyl)propyl>-4-methyl-1,3-cyclohexanediol (115030-95-0,115075-71-3,127854-64-2,127854-65-3) → (+)-(2R,5S,6S,8S,9S,11S)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol (115030-96-1,115114-83-5,127854-66-4,127910-97-8) + (-)-(2S,5S,6S,8S,9S,11S)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol (115030-96-1,115114-83-5,127854-66-4,127910-97-8)

Guidance literature:

With pyridinium p-toluenesulfonate; In benzene; for 1h; Heating; Dean-Stark conditions;

DOI:10.1016/S0040-4020(01)89182-1

Reference yield: 52.0%

benzaldehyde (100-52-7) + (+)-<1S(1S),3S,4S,6S>-6-<(tert-butyldiphenylsilyloxy)methyl>-1-<1-(hydroxymethyl)-3-(phenylsulphonyl)propyl>-4-methyl-1,3-cyclohexanediol (115030-95-0,115075-71-3,127854-64-2,127854-65-3) → (+)-(2R,5S,6S,8S,9S,11S)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol (115030-96-1,115114-83-5,127854-66-4,127910-97-8) + (-)-(2S,5S,6S,8S,9S,11S)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol (115030-96-1,115114-83-5,127854-66-4,127910-97-8)

Guidance literature:

With pyridinium p-toluenesulfonate; In benzene; for 1h; Heating; Dean-Stark conditions;

DOI:10.1016/S0040-4020(01)89182-1

Reference yield:

benzaldehyde (100-52-7) + (1R,3S,4S,6S)-1-((S)-3-Benzenesulfonyl-1-hydroxymethyl-propyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-cyclohexane-1,3-diol (115030-95-0,115075-71-3,127854-64-2,127854-65-3) → (2R*,5S*,6S*,8S*,9S*,11S*)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol (115030-96-1,115114-83-5,127854-66-4,127910-97-8) + (2S,5S,6R,8S,9S,11S)-5-(2-Benzenesulfonyl-ethyl)-11-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecan-8-ol (115030-96-1,115114-83-5,127854-66-4,127910-97-8)

Guidance literature:

With pyridinium p-toluenesulfonate; In benzene; at 80 ℃; for 2h; Yield given. Yields of byproduct given;

DOI:10.1016/S0040-4039(00)96835-7

upstream raw materials:

benzaldehyde

(1R,3S,4S,6S)-1-((S)-3-Benzenesulfonyl-1-hydroxymethyl-propyl)-6-(tert-butyl-diphenyl-silanyloxymethyl)-4-methyl-cyclohexane-1,3-diol

(2S,5S,6R,8S,9S,11S)-5-(2-Benzenesulfonyl-ethyl)-11-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecan-8-ol

(+)-(1S,3S,4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methyl-1-<1-methylene-3-(phenylsulphonyl)propyl>-1,3-cyclohexanediol

Downstream raw materials:

(2R,5S,6S,8S,9S,11S)-5-((E)-2-Benzenesulfonyl-vinyl)-11-(tert-butyl-diphenyl-silanyloxymethyl)-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecan-8-ol

C₄₉H₅₈O₉

C₄₉H₅₆O₉

(2S,6R,7S,9R,10R)-10-Benzoyloxy-5-[(2E,6E)-8-(4-benzoyloxy-1,7-dioxa-spiro[5.5]undec-2-yl)-6-methyl-octa-2,6-dien-(E)-ylidene]-9-methyl-2-phenyl-1,3-dioxa-spiro[5.5]undecane-7-carboxylic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 115030-96-1 (-)-(2S,5S,6S,8S,9S,11S)-11-<(tert-butyldiphenylsilyloxy)methyl>-9-methyl-2-phenyl-5-<2-(phenylsulphonyl)ethyl>-1,3-dioxaspiro<5.5>undecan-8-ol

Send

Send

Metric Ton KG G Pound L ML

Send

Send