Diethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

Base Information Edit

Chemical Name:Diethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
CAS No.:10354-31-1
Molecular Formula:C20H25NO6
Molecular Weight:375.422
Hs Code.:
DSSTox Substance ID:DTXSID401115066
Nikkaji Number:J1.427.385I
ChEMBL ID:CHEMBL2070323
Mol file:10354-31-1.mol

Synonyms:10354-31-1;diethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;Diethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-, 3,5-diethyl ester;Oprea1_016127;Oprea1_559884;SCHEMBL3028393;CHEMBL2070323;DTXSID401115066;STK387359;AKOS000573882;F1132-0818;Z239864066;DIETHYL 4-(4-HO-3-MEO-PH)-2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE;diethyl 4-(4-hydroxy-3-methoxy-phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;diethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5 dicarboxylate;diethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5- dicarboxylate;diethyl-2,6-dimethyl-1,4-dihydro-4-(4-hydroxy-3-methoxyphenyl)- 3,5-pyridine dicarboxylate;1,4-Dihydro-4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid diethyl ester;2,6-dimethyl-4-(3-methoxy-4-hydroxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester;3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-, diethyl ester

Suppliers and Price of Diethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of Diethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate Edit

Chemical Property:

PSA：94.09000
LogP:3.09060
XLogP3:2.9
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:375.16818752
Heavy Atom Count:27
Complexity:598

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=C(C1C2=CC(=C(C=C2)O)OC)C(=O)OCC)C)C

Technology Process of Diethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

There total 7 articles about Diethyl 4-(4-hydroxy-3-methoxyphenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 141-97-9
ethyl acetoacetate

: 121-33-5,8014-42-4
vanillin

: 10354-31-1
4-(4-hydroxy-3-methoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: With ammonium acetate; Zn[(L)proline]2; In ethanol; for 0.05h; microwave irradiation;
DOI:10.1002/hc.20197

Reference yield: 90.0%

: 631-61-8,92206-38-7
ammonium acetate

: 141-97-9
ethyl acetoacetate

: 121-33-5,8014-42-4
vanillin

: 10354-31-1
4-(4-hydroxy-3-methoxy-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester

Guidance literature:: With Silica-sulphonic acid-[BMIM][PF₆]; In neat (no solvent); at 60 ℃; for 0.333333h; Green chemistry;
DOI:10.1039/c4gc00923a