(S)-[5'-((R)-Acetylamino-methoxycarbonyl-methyl)-4,6,2'-trimethoxy-biphenyl-2-yl]-((R)-2-hydroxy-1-phenyl-ethylamino)-acetic acid methyl ester

Base Information

Chemical Name:(S)-[5'-((R)-Acetylamino-methoxycarbonyl-methyl)-4,6,2'-trimethoxy-biphenyl-2-yl]-((R)-2-hydroxy-1-phenyl-ethylamino)-acetic acid methyl ester
CAS No.:143674-60-6
Molecular Formula:C₃₁H₃₆N₂O₉
Molecular Weight:580.635
Hs Code.:

(S)-[5'-((R)-Acetylamino-methoxycarbonyl-methyl)-4,6,2'-trimethoxy-biphenyl-2-yl]-((R)-2-hydroxy-1-phenyl-ethylamino)-acetic acid methyl ester

Synonyms:

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Chemical Property of (S)-[5'-((R)-Acetylamino-methoxycarbonyl-methyl)-4,6,2'-trimethoxy-biphenyl-2-yl]-((R)-2-hydroxy-1-phenyl-ethylamino)-acetic acid methyl ester

Chemical Property:

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Technology Process of (S)-[5'-((R)-Acetylamino-methoxycarbonyl-methyl)-4,6,2'-trimethoxy-biphenyl-2-yl]-((R)-2-hydroxy-1-phenyl-ethylamino)-acetic acid methyl ester

There total 23 articles about (S)-[5'-((R)-Acetylamino-methoxycarbonyl-methyl)-4,6,2'-trimethoxy-biphenyl-2-yl]-((R)-2-hydroxy-1-phenyl-ethylamino)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 67-56-1
methanol

: (R)-Acetylamino-{2'-[(S)-cyano-((R)-2-hydroxy-1-phenyl-ethylamino)-methyl]-6,4',6'-trimethoxy-biphenyl-3-yl}-acetic acid methyl ester

: 143674-60-6,143730-44-3
(S)-[5'-((R)-Acetylamino-methoxycarbonyl-methyl)-4,6,2'-trimethoxy-biphenyl-2-yl]-((R)-2-hydroxy-1-phenyl-ethylamino)-acetic acid methyl ester

Guidance literature:: With hydrogenchloride;
DOI:10.1016/0040-4039(92)88096-N

Reference yield:

: 705-76-0
3,5-dimethoxybenzyl alcohol

: 143674-60-6,143730-44-3
(S)-[5'-((R)-Acetylamino-methoxycarbonyl-methyl)-4,6,2'-trimethoxy-biphenyl-2-yl]-((R)-2-hydroxy-1-phenyl-ethylamino)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 19 steps

1: 96 percent / NBS / CHCl₃ / 45 °C

2: 90 percent / PDC / CHCl₃

3: 85 percent / NaClO₂ / dimethylsulfoxide / 12 h / Ambient temperature

4: SOCl₂ / Heating

5: Et₃N, DMAP / CHCl₃ / 0 °C

6: 25 percent / NaOAc / Pd(PPh₃)2Cl₂ / N,N-dimethyl-acetamide / 130 °C

7: 68 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

8: 90 percent / K₂CO₃ / acetone / 3 h / Ambient temperature

9: 80 percent / NaH / tetrahydrofuran / 20 h / Ambient temperature

10: p-TsOH / methanol / 6 h / 60 °C

11: Et₃N, DMAP / CHCl₃ / Ambient temperature

12: K₂CO₃ / methanol / 0.17 h

13: PDC / dimethylformamide / 10 h / Ambient temperature

14: diethyl ether; methanol

15: 80 percent / H₂ / Pd/C (10percent)

16: 86 percent / PDC / CHCl₃

18: methanol; CHCl₃

19: 65 percent / HCl

With hydrogenchloride; dmap; sodium chlorite; N-Bromosuccinimide; lithium aluminium tetrahydride; dipyridinium dichromate; thionyl chloride; hydrogen; sodium acetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; chloroform; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0040-4039(92)88096-N

Reference yield:

: 2150-37-0
methyl 3,5-dimethoxybenzoate

: 143674-60-6,143730-44-3
(S)-[5'-((R)-Acetylamino-methoxycarbonyl-methyl)-4,6,2'-trimethoxy-biphenyl-2-yl]-((R)-2-hydroxy-1-phenyl-ethylamino)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 20 steps

1: 92 percent / LiAlH₄ / tetrahydrofuran / 10 h / Ambient temperature

2: 96 percent / NBS / CHCl₃ / 45 °C

3: 90 percent / PDC / CHCl₃

4: 85 percent / NaClO₂ / dimethylsulfoxide / 12 h / Ambient temperature

5: SOCl₂ / Heating

6: Et₃N, DMAP / CHCl₃ / 0 °C

7: 25 percent / NaOAc / Pd(PPh₃)2Cl₂ / N,N-dimethyl-acetamide / 130 °C

8: 68 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

9: 90 percent / K₂CO₃ / acetone / 3 h / Ambient temperature

10: 80 percent / NaH / tetrahydrofuran / 20 h / Ambient temperature

11: p-TsOH / methanol / 6 h / 60 °C

12: Et₃N, DMAP / CHCl₃ / Ambient temperature

13: K₂CO₃ / methanol / 0.17 h

14: PDC / dimethylformamide / 10 h / Ambient temperature

15: diethyl ether; methanol

16: 80 percent / H₂ / Pd/C (10percent)

17: 86 percent / PDC / CHCl₃

19: methanol; CHCl₃

20: 65 percent / HCl

With hydrogenchloride; dmap; sodium chlorite; N-Bromosuccinimide; lithium aluminium tetrahydride; dipyridinium dichromate; thionyl chloride; hydrogen; sodium acetate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; chloroform; N,N-dimethyl acetamide; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0040-4039(92)88096-N