(4-Methoxyphenyl)-[1-(2-morpholin-4-ylethyl)indol-3-yl]methanone

Base Information

Chemical Name:(4-Methoxyphenyl)-[1-(2-morpholin-4-ylethyl)indol-3-yl]methanone
CAS No.:103608-67-9
Molecular Formula:C22H24N2O3
Molecular Weight:364.43800
Hs Code.:
DSSTox Substance ID:DTXSID90431748
Nikkaji Number:J360.175G
Wikidata:Q82245706
ChEMBL ID:CHEMBL273606
Mol file:103608-67-9.mol

Synonyms:103608-67-9;(4-methoxyphenyl)-[1-(2-morpholin-4-ylethyl)indol-3-yl]methanone;CHEMBL273606;(4-methoxyphenyl)[1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-Methanone;DTXSID90431748;OWHRWRHRTWMBKN-UHFFFAOYSA-N;BDBM50009868;AKOS015950914;1-(2-Morpholinoethyl)-3-(4-methoxybenzoyl)-1H-indole;(4-Methoxy-phenyl)-[1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-methanone;(s-trans)-(4-Methoxy-phenyl)-[1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-methanone

Suppliers and Price of (4-Methoxyphenyl)-[1-(2-morpholin-4-ylethyl)indol-3-yl]methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (4-Methoxyphenyl)-[1-(2-morpholin-4-ylethyl)indol-3-yl]methanone

Chemical Property:

Boiling Point:562.7±50.0 °C(Predicted)
PKA:7.06±0.10(Predicted)
PSA：43.70000
Density:1.20±0.1 g/cm3(Predicted)
LogP:3.15100
XLogP3:2.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:364.17869263
Heavy Atom Count:27
Complexity:486

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(=O)C2=CN(C3=CC=CC=C32)CCN4CCOCC4

Technology Process of (4-Methoxyphenyl)-[1-(2-morpholin-4-ylethyl)indol-3-yl]methanone

There total 4 articles about (4-Methoxyphenyl)-[1-(2-morpholin-4-ylethyl)indol-3-yl]methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 3240-94-6
N-(2-chlorethyl)morpholine

: 22051-15-6
3-(4-methoxybenzoyl)indole

: 103608-67-9
(4-Methoxy-phenyl)-[1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-methanone

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; Heating;
DOI:10.1021/jm00107a034

Reference yield: 43.0%

: 201230-82-2
carbon monoxide

: 5720-07-0
4-methoxyphenylboronic acid

: C₁₄H₁₇IN₂O

: 103608-67-9
(4-Methoxy-phenyl)-[1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-methanone

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate; triethylamine; In 1,4-dioxane; at 80 ℃; for 20h; Inert atmosphere; Sealed tube; Cooling with ice;
DOI:10.1039/c9ra06594f

Reference yield:

: 26340-47-6
3-Iodo-1H-indole

: 103608-67-9
(4-Methoxy-phenyl)-[1-(2-morpholin-4-yl-ethyl)-1H-indol-3-yl]-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / N,N-dimethyl-formamide / 4 h / 20 °C

2: triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium carbonate / 1,4-dioxane / 20 h / 80 °C / Inert atmosphere; Sealed tube; Cooling with ice

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; potassium carbonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1039/c9ra06594f