2-({2-[2-[(2-methylcarbamoyl-benzoylamino)-methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetylamino}-methyl)-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:2-({2-[2-[(2-methylcarbamoyl-benzoylamino)-methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetylamino}-methyl)-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:664967-03-7
Molecular Formula:C₃₆H₄₇N₉O₉
Molecular Weight:749.824
Hs Code.:

2-({2-[2-[(2-methylcarbamoyl-benzoylamino)-methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetylamino}-methyl)-4-(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid <i>tert</i>-butyl ester

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Chemical Property of 2-({2-[2-[(2-methylcarbamoyl-benzoylamino)-methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetylamino}-methyl)-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of 2-({2-[2-[(2-methylcarbamoyl-benzoylamino)-methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetylamino}-methyl)-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 13 articles about 2-({2-[2-[(2-methylcarbamoyl-benzoylamino)-methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetylamino}-methyl)-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77450-00-1
(2R,4R)-4-hydroxyproline-1,2-dicarboxylic acid 1-tert-butyl 2-ethyl ester

: 664967-03-7
2-({2-[2-[(2-methylcarbamoyl-benzoylamino)-methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetylamino}-methyl)-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 90 percent / diisopropyl azodicarboxylate; Ph₃P / tetrahydrofuran / 18 h / 20 °C

2: 91 percent / aq. NH₃ / methanol / 5 h / 20 °C

3: 62 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 18 h / 20 °C

4: 69 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

5: 63 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

6: 89 percent / aq. CH₃NH₂ / 1 h / 40 °C

7: 97 percent / CH₂Cl₂; acetonitrile / -8 - 20 °C

8: 98 percent / DIPEA / dimethylformamide / 18 h / 20 °C

9: H₂O / 0.67 h / 20 °C

With ammonium hydroxide; lithium borohydride; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylamine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b306156f

Reference yield:

: 77450-02-3
N-(tert-butoxycarbonyl)-trans-4-hydroxy-D-proline ethyl ester

: 664967-03-7
2-({2-[2-[(2-methylcarbamoyl-benzoylamino)-methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetylamino}-methyl)-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 62 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 18 h / 20 °C

2: 69 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

3: 63 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

4: 89 percent / aq. CH₃NH₂ / 1 h / 40 °C

5: 97 percent / CH₂Cl₂; acetonitrile / -8 - 20 °C

6: 98 percent / DIPEA / dimethylformamide / 18 h / 20 °C

7: H₂O / 0.67 h / 20 °C

With lithium borohydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylamine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b306156f

Reference yield:

: 4330-20-5
N-3-benzoylthymine

: 664967-03-7
2-({2-[2-[(2-methylcarbamoyl-benzoylamino)-methyl]-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidin-1-yl]-acetylamino}-methyl)-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 62 percent / diethyl azodicarboxylate; Ph₃P / tetrahydrofuran / 18 h / 20 °C

2: 69 percent / LiBH₄ / tetrahydrofuran / 0 - 20 °C

3: 63 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 18 h / 20 °C

4: 89 percent / aq. CH₃NH₂ / 1 h / 40 °C

5: 97 percent / CH₂Cl₂; acetonitrile / -8 - 20 °C

6: 98 percent / DIPEA / dimethylformamide / 18 h / 20 °C

7: H₂O / 0.67 h / 20 °C

With lithium borohydride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; methylamine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1039/b306156f