2-(1-acetyl-2-(dimethylamino)vinyl)-4,6-bis-benzyloxybenzoic acid methyl ester

Base Information

• Chemical Name: 2-(1-acetyl-2-(dimethylamino)vinyl)-4,6-bis-benzyloxybenzoic acid methyl ester
• CAS No.: 426828-26-4
• Molecular Formula: C₂₈H₂₉NO₅
• Molecular Weight: 459.542
• Mol file: 426828-26-4.mol

Synonyms:

Chemical Property of 2-(1-acetyl-2-(dimethylamino)vinyl)-4,6-bis-benzyloxybenzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1-acetyl-2-(dimethylamino)vinyl)-4,6-bis-benzyloxybenzoic acid methyl ester

There total 5 articles about 2-(1-acetyl-2-(dimethylamino)vinyl)-4,6-bis-benzyloxybenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N,N-dimethyl-formamide dimethyl acetal (4637-24-5) + 2,4-bis-benzyloxy-6-(2-oxopropyl)benzoic acid (426828-24-2) → 2-(1-acetyl-2-(dimethylamino)vinyl)-4,6-bis-benzyloxybenzoic acid methyl ester (426828-26-4)

Guidance literature:

In toluene; for 5h; Heating;

DOI:10.1021/jo010789b

Reference yield:

2,4-bis-benzyloxy-6-methoxycarbonylmethylbenzoic acid methyl ester (37172-97-7) → 2-(1-acetyl-2-(dimethylamino)vinyl)-4,6-bis-benzyloxybenzoic acid methyl ester (426828-26-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 93 percent / potassium hydroxide / ethanol; H₂O / 24 h / Heating

2.1: pyridine / diethyl ether / 20 °C

2.2: 76 percent / sodium hydroxide / H₂O / 0.5 h / 60 °C

3.1: 87 percent / toluene / 5 h / Heating

With pyridine; potassium hydroxide; In diethyl ether; ethanol; water; toluene;

DOI:10.1021/jo010789b

Reference yield:

methyl <3,5-dihydroxy-2-(methoxycarbonyl)phenyl>acetate (6110-30-1) → 2-(1-acetyl-2-(dimethylamino)vinyl)-4,6-bis-benzyloxybenzoic acid methyl ester (426828-26-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 87 percent / potassium carbonate; potassium iodide / acetone / 48 h / Heating

2.1: 93 percent / potassium hydroxide / ethanol; H₂O / 24 h / Heating

3.1: pyridine / diethyl ether / 20 °C

3.2: 76 percent / sodium hydroxide / H₂O / 0.5 h / 60 °C

4.1: 87 percent / toluene / 5 h / Heating

With pyridine; potassium hydroxide; potassium carbonate; potassium iodide; In diethyl ether; ethanol; water; acetone; toluene;

DOI:10.1021/jo010789b

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

2,4-bis-benzyloxy-6-(2-oxopropyl)benzoic acid

methyl <3,5-dihydroxy-2-(methoxycarbonyl)phenyl>acetate

2,4-bis-benzyloxy-6-methoxycarbonylmethylbenzoic acid methyl ester