37172-97-7

Upstream product

• 6110-30-1 methyl <3,5-dihydroxy-2-(methoxycarbonyl)phenyl>acetate 
• 100-39-0 benzyl bromide 
• 100-51-6 benzyl alcohol 

Downstream Products

• 96864-17-4 2,4-bis-benzyloxy-6-carboxymethylbenzoic acid methyl ester 
• 790699-37-5 6,8-bis-benzyloxy-isochroman-1,3-dione 
• 790699-58-0 (3R)-6,8-dibenzyloxy-9-hydroxy-3-methyl-3,4-dihydro-2H-anthracen-1-one 
• 849692-99-5 6,8-bis-benzyloxy-9-hydroxy-2-(1-hydroxy-hexyl)-3-methyl-3,4-dihydro-2H-anthracen-1-one 
• 426828-24-2 2,4-bis-benzyloxy-6-(2-oxopropyl)benzoic acid 
• 426828-26-4 2-(1-acetyl-2-(dimethylamino)vinyl)-4,6-bis-benzyloxybenzoic acid methyl ester 
• 96864-18-5 methyl 2-carboxy-3,5-dibenzyloxyhomophthalate 
• 1310490-73-3 2-(7-hydroxy-1-oxooctyl)-3,5-dihydroxybenzeneacetic acid ethyl ester 
• 1309953-46-5 methyl 2,4-bis(benzyloxy)-6-(2,2-dimethoxyethyl)benzoate 
• 1309953-47-6 2,4-bis(benzyloxy)-6-(2,2-dimethoxyethyl)benzaldehyde 
• 1309953-48-7 1-(2,4-bis(benzyloxy)-6-(2,2-dimethoxyethyl)phenyl)hex-5-en-1-ol 
• 1309953-49-8 ethyl 2-(3,5-bis(benzyloxy)-2-(hex-5-enoyl)phenyl)acetate 
• 1309953-50-1 ethyl (E)-(3,5-bis(benzyloxy)-2-(7-hydroxyoct-5-enoyl)phenyl)acetate 
• 1309953-51-2 ethyl 2-(2-((S,E)-7-(benzyloxy)oct-5-enoyl)-3,5-bis(benzyloxy)phenyl)acetate 

Relevant academic research and scientific papers

Synthesis of 4-acetylisocoumarin: First total syntheses of AGI-7 and sescandelin

A practical synthetic route to 4-acetylisocoumarins and the first total synthesis of AGI-7 (5) and sescandelin (4) are described. The readily available homophthalate 8 was transformed to the vinylogous amide ester 13 in high overall yield. Upon treatment of 13 with refluxing aqueous formic acid, the desired 4-acetylisocoumarin (5) and its regioisomer 3-methyl-4-formylisocoumarin (17) were produced in a 3:1 ratio. After separation of the desired product (5) from the unwanted minor isomer, the enantioselective reduction of AGI-7 by borane in the presence of Corey's (S)-oxazaborolidine reagent afforded (+)-sescandelin (4) with a 93% ee.

Synthesis and structural revision of phomopsin B, a novel polyketide carrying a 10-membered cyclic-ether ring

Total synthesis of the proposed structure 2 for phomopsin B was achieved by using an intramolecular olefin metathesis as a key step. The spectral data, however, did not match with those of the natural product reported. Re-examination of the reported NMR data led to the structural revision of phomopsin B to known dothiorelone A 18. The R configuration of dothiorelone A was determined by total synthesis through a cross-metathesis with a chiral olefin 19.

New DNA binding ligands as a model of chromomycin A3

Small molecules with DNA-binding affinity within the minor groove have become of great interest. In this study, new DNA-binding ligands were designed to mimic Chromomycin A3 (CRA3), which contains a hydroxylated tetrahydroanthracene

Synthesis of Siphulin, a Naturally Occurring Homoflavone

Siphulin, the only homoflavone known in Nature, is synthesized from 2-hydroxy-4-benzyloxy-6-heptylacetophenone and methyl 2-carboxy-3,5-dibenzyloxyhomophthalate, reacting, in the presence of sodium hydride, to give tri-O-benzylprotosiphulin, convertible,