(1R)-1-(2,4-dichlorophenyl)ethan-1-ol

Base Information

• Chemical Name: (1R)-1-(2,4-dichlorophenyl)ethan-1-ol
• CAS No.: 415679-40-2
• Molecular Formula: C₈H₈Cl₂O
• Molecular Weight: 191.057
• UNII: M32HZ82S7G
• Nikkaji Number: J1.188.210B
• Mol file: 415679-40-2.mol

Synonyms:(1R)-1-(2,4-dichlorophenyl)ethan-1-ol;415679-40-2;(R)-1-(2,4-dichlorophenyl)ethanol;(1R)-1-(2,4-dichlorophenyl)ethanol;M32HZ82S7G;1-(2,4-Dichlorophenyl)ethanol, (R)-;UNII-M32HZ82S7G;SCHEMBL14992635;KWZDYNBHZMQRLS-RXMQYKEDSA-N;EN300-52748;(alphaR)-2,4-Dichloro-alpha-methylbenzenemethanol;Benzenemethanol, 2,4-dichloro-alpha-methyl-, (alphaR)-;(.ALPHA.R)-2,4-DICHLORO-.ALPHA.-METHYLBENZENEMETHANOL;BENZENEMETHANOL, 2,4-DICHLORO-.ALPHA.-METHYL-, (.ALPHA.R)-

Chemical Property of (1R)-1-(2,4-dichlorophenyl)ethan-1-ol

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 189.9952203
• Heavy Atom Count: 11
• Complexity: 129

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C1=C(C=C(C=C1)Cl)Cl)O
• Isomeric SMILES: C[C@H](C1=C(C=C(C=C1)Cl)Cl)O

Technology Process of (1R)-1-(2,4-dichlorophenyl)ethan-1-ol

There total 21 articles about (1R)-1-(2,4-dichlorophenyl)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

→ 2,4-dichloro-α-methylbenzyl alcohol (1475-13-4,415679-40-2)

Guidance literature:

With C₃₇H₄₃MoN₃O₂P; sodium triethylborohydride; isopropyl alcohol; sodium hydroxide; In tetrahydrofuran; at 90 ℃; for 2h; Schlenk technique; Inert atmosphere;

Reference yield: 99.0%

1-(2,4-dichlorophenyl)ethan-1-one (2234-16-4) → 2,4-dichloro-α-methylbenzyl alcohol (1475-13-4,415679-40-2)

Guidance literature:

With sodium borohydrid; In methanol; water;

Reference yield: 99.0%

1-(2,4-dichlorophenyl)ethan-1-one (2234-16-4) → (S)-1-(2',4'-dichlorophenyl)-1-ethanol (179237-92-4,415679-40-2)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C₅₃H₇₃FeN₂O₂PS; hydrogen; lithium tert-butoxide; In isopropyl alcohol; at 25 - 30 ℃; for 12h; under 22801.5 Torr; enantioselective reaction; Autoclave;

DOI:10.1021/acs.joc.8b01276

upstream raw materials:

aluminum isopropoxide

1-(2,4-dichlorophenyl)ethan-1-one

diethyl ether

2,4-dichloro-1-iodo-benzene

Downstream raw materials:

ethyl 4-(2,4-dichlorophenyl)-2,4-dioxobutyrate

ethyl 5-(2,4-dichlorophenyl)isoxazole-3-carboxylate

(5-(2,4-dichlorophenyl)isoxazol-3-yl)methanol

((S)-4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)-2-(hydroxymethyl)piperazin-1-yl)((R)-pyrrolidin-2-yl)methanone