7-{4-[2-(4-dimethylamino-piperidin-1-yl)-acetyl]-piperazin-1-ylmethyl}-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Base Information

Chemical Name:7-{4-[2-(4-dimethylamino-piperidin-1-yl)-acetyl]-piperazin-1-ylmethyl}-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide
CAS No.:1215384-57-8
Molecular Formula:C₃₆H₅₃N₇O₅S
Molecular Weight:695.927
Hs Code.:

7-{4-[2-(4-dimethylamino-piperidin-1-yl)-acetyl]-piperazin-1-ylmethyl}-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

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Chemical Property of 7-{4-[2-(4-dimethylamino-piperidin-1-yl)-acetyl]-piperazin-1-ylmethyl}-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

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Technology Process of 7-{4-[2-(4-dimethylamino-piperidin-1-yl)-acetyl]-piperazin-1-ylmethyl}-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

There total 15 articles about 7-{4-[2-(4-dimethylamino-piperidin-1-yl)-acetyl]-piperazin-1-ylmethyl}-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 695179-07-8
N-(3-amino-5-tert-butyl-2-methoxy-phenyl)-methanesulphonamide hydrochloride

: 1215384-57-8
7-{4-[2-(4-dimethylamino-piperidin-1-yl)-acetyl]-piperazin-1-ylmethyl}-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 12 h / 50 °C

2.1: acetic acid / 1,2-dichloro-ethane / 0.5 h / 20 °C

2.2: 4 h

3.1: hydrogenchloride; isopropyl alcohol / 12 h / 20 °C

3.2: pH 9

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; HATU; In dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 50709-33-6
2-bromophenylhydrazine hydrochloride

: 1215384-57-8
7-{4-[2-(4-dimethylamino-piperidin-1-yl)-acetyl]-piperazin-1-ylmethyl}-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydroxide / toluene / 1 h

2.1: toluene-4-sulfonic acid / toluene / 16 h / Reflux; Water separator

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

3.2: 12 h / 20 °C

4.1: sodium hydroxide; methanol / 3 h / 20 °C

4.2: pH 2

5.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

5.2: 2.5 h / 20 °C

6.1: caesium carbonate / palladium diacetate; XPhos / water; tetrahydrofuran / 12 h / 80 °C / Inert atmosphere

7.1: hydrogenchloride; isopropyl alcohol / 12 h / 20 °C

7.2: pH 9

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

9.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; methanol; sodium hydride; potassium carbonate; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; sodium hydroxide; palladium diacetate; toluene-4-sulfonic acid; XPhos; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 16732-66-4
2-bromophenylhydrazine

: 1215384-57-8
7-{4-[2-(4-dimethylamino-piperidin-1-yl)-acetyl]-piperazin-1-ylmethyl}-1-methyl-1H-indole-2-carboxylic acid-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenyl)-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / toluene / 16 h / Reflux; Water separator

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

2.2: 12 h / 20 °C

3.1: sodium hydroxide; methanol / 3 h / 20 °C

3.2: pH 2

4.1: triethylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / ethyl acetate; tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere

4.2: 2.5 h / 20 °C

5.1: caesium carbonate / palladium diacetate; XPhos / water; tetrahydrofuran / 12 h / 80 °C / Inert atmosphere

6.1: hydrogenchloride; isopropyl alcohol / 12 h / 20 °C

6.2: pH 9

7.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; methanol; sodium hydride; potassium carbonate; caesium carbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; isopropyl alcohol; sodium hydroxide; palladium diacetate; toluene-4-sulfonic acid; XPhos; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;