Technology Process of 4-(3,4-dimethoxyphenyl)-5-(4-methoxyphenyl)penta-(2E,4Z)-dienoyl azide
There total 7 articles about 4-(3,4-dimethoxyphenyl)-5-(4-methoxyphenyl)penta-(2E,4Z)-dienoyl azide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium azide;
In
acetone;
at 20 ℃;
for 2h;
Cooling with ice;
DOI:10.1021/jo2017247
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium ethanolate / ethanol / 1 h / 85 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / hexane; dichloromethane / 3.5 h / -78 - 20 °C
2.2: 0.5 h / 20 °C
3.1: toluene / 4 h / Inert atmosphere; Reflux
4.1: potassium hydroxide / ethanol; water / 3 h / Reflux
5.1: oxalyl dichloride / toluene / 5 h / 80 °C
6.1: sodium azide / acetone / 2 h / 20 °C / Cooling with ice
With
sodium azide; oxalyl dichloride; sodium ethanolate; diisobutylaluminium hydride; potassium hydroxide;
In
ethanol; hexane; dichloromethane; water; acetone; toluene;
1.1: Knoevenagel condensation / 3.1: Wittig reaction;
DOI:10.1021/jo2017247
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium hydroxide / ethanol; water / 3 h / Reflux
2: oxalyl dichloride / toluene / 5 h / 80 °C
3: sodium azide / acetone / 2 h / 20 °C / Cooling with ice
With
sodium azide; oxalyl dichloride; potassium hydroxide;
In
ethanol; water; acetone; toluene;
DOI:10.1021/jo2017247
