C₁₅H₁₁BrF₂O₂

Base Information

• Chemical Name: C₁₅H₁₁BrF₂O₂
• CAS No.: 1042702-74-8
• Molecular Formula: C₁₅H₁₁BrF₂O₂
• Molecular Weight: 341.152
• Mol file: 1042702-74-8.mol

Synonyms:

Chemical Property of C₁₅H₁₁BrF₂O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₅H₁₁BrF₂O₂

There total 4 articles about C₁₅H₁₁BrF₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C15H12F2O2 (1042702-72-6) → C15H11BrF2O2 (1042702-74-8)

Guidance literature:

With phenyltrimethylammonium tribromide; In methanol; dichloromethane; at 20 ℃;

DOI:10.1139/V10-143

Reference yield:

4-bromo-2,5-difluoro phenol (486424-36-6) → C15H11BrF2O2 (1042702-74-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C

3: phenyltrimethylammonium tribromide / methanol; dichloromethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenyltrimethylammonium tribromide; potassium carbonate; In methanol; dichloromethane; toluene; acetonitrile; 2: Stille coupling;

DOI:10.1139/V10-143

Reference yield:

1-(benzyloxy)-4-bromo-2,5-difluorobenzene (901238-24-2) → C15H11BrF2O2 (1042702-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 100 °C

2: phenyltrimethylammonium tribromide / methanol; dichloromethane / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; phenyltrimethylammonium tribromide; In methanol; dichloromethane; toluene; 1: Stille coupling;

DOI:10.1139/V10-143

upstream raw materials:

4-bromo-2,5-difluoro phenol

1-(benzyloxy)-4-bromo-2,5-difluorobenzene

C₁₅H₁₂F₂O₂

2,5-difluorophenol

Downstream raw materials:

C₂HF₃O₂*C₁₂H₁₃F₂NO₄

C₂₄H₂₇F₂NO₆