901238-24-2

Basic information

• Product Name: 1-Benzyloxy-4-bromo-2,5-difluorobenzene
• Synonyms: 1-Benzyloxy-4-bromo-2,5-difluorobenzene
• CAS NO: 901238-24-2
• Molecular Formula: C₁₃H₉BrF₂O
• Molecular Weight: 299.1107664
• Mol File: 901238-24-2.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Benzyloxy-4-bromo-2,5-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyloxy-4-bromo-2,5-difluorobenzene(901238-24-2)
• EPA Substance Registry System: 1-Benzyloxy-4-bromo-2,5-difluorobenzene(901238-24-2)

Safety Data

• Hazardous Substances Data: 901238-24-2(Hazardous Substances Data)

Usage

Chemical structure

A benzene ring substituted with a bromine atom, two fluorine atoms, and a benzyloxy group.

Application

Often used as a building block in the synthesis of various pharmaceuticals and organic compounds.

Potential use

Identified as a potential intermediate in the production of novel fluorinated pharmaceuticals.

Structural features

Unique structural features and reactivity.

Safety precautions

Important to handle with care as it may pose certain health hazards if not properly managed.

Upstream product

• 2713-31-7 2,5-difluorophenol 
• 486424-36-6 4-bromo-2,5-difluoro phenol 
• 100-39-0 benzyl bromide 

Downstream Products

• 1181566-69-7 1-(2,5-difluoro-4-hydroxyphenyl)-1H-indol-4-ol 
• 1042702-72-6 C₁₅H₁₂F₂O₂ 
• 1042702-80-6 C₂HF₃O₂*C₁₂H₁₃F₂NO₄ 
• 1042702-77-1 C₂₄H₂₇F₂NO₆ 
• 1042702-74-8 C₁₅H₁₁BrF₂O₂ 
• 918524-01-3 (4-benzyloxy-2,5-difluoro-phenyl)-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol 
• 1181567-04-3 1-{2,5-difluoro-4-[(phenylmethyl)oxy]phenyl}-4-[(phenylmethyl)oxy]-1H-indole 

Relevant articles and documents

P-Hydroxyphenacyl photoremovable protecting groups Robust photochemistry despite substituent diversity

A broadly based investigation of the effects of a diverse array of substituents on the photochemical rearrangement of p-hydroxyphenacyl esters has demonstrated that common substituents such as F, MeO, CN, CO2R, CONH2, and CH3 have little effect on the rate and quantum efficiencies for the photo-Favorskii rearrangement and the release of the acid leaving group or on the lifetimes of the reactive triplet state. A decrease in the quantum yields across all substituents was observed for the release and rearrangement when the photolyses were carried out in buffered aqueous media at pHs that exceeded the ground-state pKa of the chromophore where the conjugate base is the predominant form. Otherwise, substituents have only a very modest effect on the photoreaction of these robust chromophores.

PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS

Compounds of formula III which are active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.