(S)-3-tert-Butoxycarbonylamino-N-[(S)-1-((S)-2-hydroxy-1-methoxycarbonyl-ethylcarbamoyl)-2-phenyl-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Name:(S)-3-tert-Butoxycarbonylamino-N-[(S)-1-((S)-2-hydroxy-1-methoxycarbonyl-ethylcarbamoyl)-2-phenyl-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester
CAS No.:82155-27-9
Molecular Formula:C₂₆H₃₄N₄O₁₁
Molecular Weight:578.576
Hs Code.:

(S)-3-tert-Butoxycarbonylamino-N-[(S)-1-((S)-2-hydroxy-1-methoxycarbonyl-ethylcarbamoyl)-2-phenyl-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Chemical Property of (S)-3-tert-Butoxycarbonylamino-N-[(S)-1-((S)-2-hydroxy-1-methoxycarbonyl-ethylcarbamoyl)-2-phenyl-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester

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Technology Process of (S)-3-tert-Butoxycarbonylamino-N-[(S)-1-((S)-2-hydroxy-1-methoxycarbonyl-ethylcarbamoyl)-2-phenyl-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester

There total 12 articles about (S)-3-tert-Butoxycarbonylamino-N-[(S)-1-((S)-2-hydroxy-1-methoxycarbonyl-ethylcarbamoyl)-2-phenyl-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 82155-27-9
(S)-3-tert-Butoxycarbonylamino-N-[(S)-1-((S)-2-hydroxy-1-methoxycarbonyl-ethylcarbamoyl)-2-phenyl-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / N-methylmorpholine, dicyclocarbodiimide / CHCl₃; dimethylformamide / Ambient temperature

2: 83 percent / hydrogen, 3.5M HCl / Pd black / methanol; acetone / 5 h

3: dicyclohexylcarbodiimide / dimethylformamide; tetrahydrofuran / 24 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0008-6215(84)85199-X

Reference yield:

: 7536-58-5,98482-77-0
BOC-L-aspartic acid 4-benzyl ester

: 82155-27-9
(S)-3-tert-Butoxycarbonylamino-N-[(R)-1-((S)-2-hydroxy-1-methoxycarbonyl-ethylcarbamoyl)-2-phenyl-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine, dicyclohexylcarbodiimide / dimethylformamide; CHCl₃ / Ambient temperature

2: 92 percent / hydrogen, 3.5M HCl / Pd black / methanol; dioxane / 5 h

3: dicyclohexylcarbodiimide / dimethylformamide; tetrahydrofuran / 24 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/0008-6215(84)85199-X

Reference yield:

: 1161-13-3
N-Cbz-L-Phe

: 82155-27-9
(S)-3-tert-Butoxycarbonylamino-N-[(S)-1-((S)-2-hydroxy-1-methoxycarbonyl-ethylcarbamoyl)-2-phenyl-ethyl]-succinamic acid 2,5-dioxo-pyrrolidin-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 78 percent / N-methylmorpholine, dicyclihexylcarbodiimide / dimethylformamide; CHCl₃ / Ambient temperature

2: 89 percent / hydrogen, 3.5M HCl / Pd black / methanol; dioxane / 5 h

3: 78 percent / N-methylmorpholine, dicyclocarbodiimide / CHCl₃; dimethylformamide / Ambient temperature

4: 83 percent / hydrogen, 3.5M HCl / Pd black / methanol; acetone / 5 h

5: dicyclohexylcarbodiimide / dimethylformamide; tetrahydrofuran / 24 h / 0 °C

With 4-methyl-morpholine; hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0008-6215(84)85199-X