Trifluoro-methanesulfonic acid (2R,4aR,6R,7S,8S,8aR)-7-benzyloxy-8-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl ester

Base Information

• Chemical Name: Trifluoro-methanesulfonic acid (2R,4aR,6R,7S,8S,8aR)-7-benzyloxy-8-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl ester
• CAS No.: 538370-37-5
• Molecular Formula: C₂₉H₂₉F₃O₉S
• Molecular Weight: 610.605
• Mol file: 538370-37-5.mol

Synonyms:

Chemical Property of Trifluoro-methanesulfonic acid (2R,4aR,6R,7S,8S,8aR)-7-benzyloxy-8-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Trifluoro-methanesulfonic acid (2R,4aR,6R,7S,8S,8aR)-7-benzyloxy-8-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl ester

There total 3 articles about Trifluoro-methanesulfonic acid (2R,4aR,6R,7S,8S,8aR)-7-benzyloxy-8-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

silver trifluoromethanesulfonate (2923-28-6) + methyl 2-O-benzyl-4,6-O-benzylidene-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside (177943-74-7) → Trifluoro-methanesulfonic acid (2R,4aR,6R,7S,8S,8aR)-7-benzyloxy-8-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl ester (538370-37-5)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine; benzenesulfenyl chloride;

DOI:10.1016/S0040-4039(03)00102-3

Reference yield: 64.0%

trifluoromethylsulfonic anhydride (358-23-6) + methyl 2-O-benzyl-4,6-O-benzylidene-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside (177943-74-7) → Trifluoro-methanesulfonic acid (2R,4aR,6R,7S,8S,8aR)-7-benzyloxy-8-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl ester (538370-37-5)

Guidance literature:

With 1-benzenesulfinyl piperidine; 2,4,6-tri-tert-butylpyrimidine;

DOI:10.1016/S0040-4039(03)00102-3

Reference yield: 60.0%

trifluoromethylsulfonic anhydride (358-23-6) + phenyl 2-O-benzyl-4,6-O-benzylidene-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside S-oxide → Trifluoro-methanesulfonic acid (2R,4aR,6R,7S,8S,8aR)-7-benzyloxy-8-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yl ester (538370-37-5)

Guidance literature:

With 2,6-di-tert-butyl-4-methylpyridine;

DOI:10.1016/S0040-4039(03)00102-3

upstream raw materials:

trifluoromethylsulfonic anhydride

methyl 2-O-benzyl-4,6-O-benzylidene-3-O-p-methoxybenzyl-1-thio-α-D-mannopyranoside

silver trifluoromethanesulfonate

Downstream raw materials:

(2R,4aR,6S,7S,8S,8aR)-6-((2R,3S,4R,5R,6R)-5-Azido-4-benzyloxy-2-benzyloxymethyl-6-pent-4-enyloxy-tetrahydro-pyran-3-yloxy)-7-benzyloxy-8-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine

C₈₆H₉₈N₂O₁₉S₂Si

C₇₁H₈₆N₆O₁₄Si

[(2R,4aR,6S,7S,8S,8aR)-6-((2R,3S,4R,5R,6R)-5-Azido-4-benzyloxy-2-benzyloxymethyl-6-pent-4-enyloxy-tetrahydro-pyran-3-yloxy)-7-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-8-yloxy]-tert-butyl-dimethyl-silane