4-(((2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

Base Information

Chemical Name:4-(((2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid
CAS No.:1289570-74-6
Molecular Formula:C₃₂H₃₁Cl₂F₂N₃O₄
Molecular Weight:630.519
Hs Code.:

4-(((2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

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Chemical Property of 4-(((2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

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Technology Process of 4-(((2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

There total 10 articles about 4-(((2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: rac-4-(((2S,3S,4S)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

: 1289570-73-5
rac-4-(((2S,3S,4S)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

: 1289570-74-6
4-(((2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

Guidance literature:: With Kromasil 5-CelluCoat OD prep column; In methanol; Purification / work up; Resolution of racemate;

Reference yield:

: 89469-52-3
2-methoxy-4-cyano-benzoic acid

: 1289570-73-5
rac-4-(((2S,3S,4S)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

: 1289570-74-6
4-(((2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: toluene-4-sulfonic acid / water / 16 h / Reflux; Inert atmosphere

2: hydrogen / Raney-nickel / water; methanol / 16 h / 2585.81 Torr

3: N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere

4: dichloromethane / 16 h / 20 °C

5: water; lithium hydroxide / tetrahydrofuran / 48 h / 20 °C

6: Kromasil 5-CelluCoat OD prep column / methanol / Resolution of racemate

With water; hydrogen; toluene-4-sulfonic acid; lithium hydroxide; Raney-nickel; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 85070-48-0
2-fluoro-3-chlorobenzaldehyde

: 1289570-73-5
rac-4-(((2S,3S,4S)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

: 1289570-74-6
4-(((2R,3R,4R)-2-(3-chloro-2-fluorophenyl)-3-(4-chloro-2-fluorophenyl)-3-cyano-4-neopentylpyrrolidine-1-carboxamido)methyl)-2-methoxybenzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane; tetrahydrofuran / 20 °C

2: potassium hydroxide / dimethyl sulfoxide / 20 °C

3: dichloromethane / 16 h / 20 °C

4: water; lithium hydroxide / tetrahydrofuran / 48 h / 20 °C

5: Kromasil 5-CelluCoat OD prep column / methanol / Resolution of racemate

With water; lithium hydroxide; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide;