1-carbamoyl-3-cyclohexylmethoxy-6-methylaminosulfonyl-β-carboline

Base Information

Chemical Name:1-carbamoyl-3-cyclohexylmethoxy-6-methylaminosulfonyl-β-carboline
CAS No.:1174589-03-7
Molecular Formula:C₂₀H₂₄N₄O₄S
Molecular Weight:416.501
Hs Code.:

Synonyms:

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Chemical Property of 1-carbamoyl-3-cyclohexylmethoxy-6-methylaminosulfonyl-β-carboline

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Technology Process of 1-carbamoyl-3-cyclohexylmethoxy-6-methylaminosulfonyl-β-carboline

There total 8 articles about 1-carbamoyl-3-cyclohexylmethoxy-6-methylaminosulfonyl-β-carboline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 74214-62-3
ethyl 9H-pyrido[3,4-b]indole-3-carboxylate

: 1174589-03-7
1-carbamoyl-3-cyclohexylmethoxy-6-methylaminosulfonyl-β-carboline

Guidance literature:: Multi-step reaction with 8 steps

1: hydrazine hydrate / methanol / 6 h / Reflux

2: hydrogenchloride; sodium nitrite / water / 0.5 h / 0 - 5 °C

3: hydrogenchloride / water / 0.5 h / Reflux

4: hydrogenchloride; sodium nitrite / 2.5 h / 0 - 5 °C

5: 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride / 24 h / Reflux; Inert atmosphere

6: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.17 h / 10 - 15 °C

7: chlorosulfonic acid / 0 - 5 °C

8: water / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; chlorosulfonic acid; sulfuric acid; dihydrogen peroxide; sodium hydride; hydrazine hydrate; iron(II) sulfate; sodium nitrite; In methanol; water; 3: Curtius rearrangement / 6: Minisci reaction;
DOI:10.1080/00397911.2010.546552

Reference yield:

: 73834-77-2
3-amino-9H-β-carboline

: 1174589-03-7
1-carbamoyl-3-cyclohexylmethoxy-6-methylaminosulfonyl-β-carboline

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; sodium nitrite / 2.5 h / 0 - 5 °C

2: 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride / 24 h / Reflux; Inert atmosphere

3: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.17 h / 10 - 15 °C

4: chlorosulfonic acid / 0 - 5 °C

5: water / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogenchloride; chlorosulfonic acid; sulfuric acid; dihydrogen peroxide; sodium hydride; iron(II) sulfate; sodium nitrite; In water; 3: Minisci reaction;
DOI:10.1080/00397911.2010.546552

Reference yield:

: 91985-80-7
3-chloro-9H-pyrido[3,4-b]indole

: 1174589-03-7
1-carbamoyl-3-cyclohexylmethoxy-6-methylaminosulfonyl-β-carboline

Guidance literature:: Multi-step reaction with 4 steps

1: 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride / 24 h / Reflux; Inert atmosphere

2: sulfuric acid; dihydrogen peroxide; iron(II) sulfate / water / 0.17 h / 10 - 15 °C

3: chlorosulfonic acid / 0 - 5 °C

4: water / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; chlorosulfonic acid; sulfuric acid; dihydrogen peroxide; sodium hydride; iron(II) sulfate; In water; 2: Minisci reaction;
DOI:10.1080/00397911.2010.546552