Technology Process of ethyl (4-isopropyl-2,3,5-trimethoxy)dihydrocinnamate
There total 2 articles about ethyl (4-isopropyl-2,3,5-trimethoxy)dihydrocinnamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 18 h / 0 - 20 °C / Inert atmosphere
2: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 13 h / 0 - 20 °C / Inert atmosphere
3: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; sulfur trioxide pyridine complex; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium chloride;
In
ethanol; dichloromethane; dimethyl sulfoxide; acetonitrile;
1: |Parikh-Doering Oxidation / 2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tet.2013.04.049
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 13 h / 0 - 20 °C / Inert atmosphere
2: palladium 10% on activated carbon; hydrogen / ethanol / 12 h / 20 °C / Inert atmosphere
With
palladium 10% on activated carbon; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; lithium chloride;
In
ethanol; acetonitrile;
1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.tet.2013.04.049
- Guidance literature:
-
Multi-step reaction with 2 steps
1: lithium hydroxide monohydrate / tetrahydrofuran; water / 18 h / 20 °C / Inert atmosphere
2: oxalyl dichloride / dichloromethane; N,N-dimethyl-formamide / 2.33 h / 0 °C / Inert atmosphere
With
oxalyl dichloride; lithium hydroxide monohydrate;
In
tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.tet.2013.04.049
