866464-91-7

Upstream product

• 135-77-3 1,2,4-trimethoxy-benzene 
• 60241-77-2 1,2,4-trimethoxy-3-(prop-1-en-2-yl)benzene 
• 60241-75-0 methyl 2,3,6-trimethoxybenzoate 
• 60241-74-9 2,3,6-trimethoxybenzoic acid 
• 60241-76-1 3-(1-methyl-1-hydroxyethyl)-1,2,4-trimethoxybenzene 
• 60241-78-3 3-(1-methylethyl)-1,2,4-trimethoxybenzene 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 1352034-35-5 C₃₃H₄₁F₃O₆ 
• 1352034-36-6 C₃₃H₄₁F₃O₆ 
• 156723-10-3 3-ethenyl-4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenylmethyl]-2-cyclohexenone 
• 156723-08-9 4,4-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenyl-methyl]-1,3-cyclohexanedione 
• 156723-09-0 3-methoxy-6,6-dimethyl-2-[4-(1-methylethyl)-2,3,5-trimethoxyphenylmethyl]-2-cyclohexenone 
• 1217296-80-4 4-isopropyl-2,3,5-trimethoxydihydrocinnamic acid 
• 1217296-89-3 ethyl (4-isopropyl-2,3,5-trimethoxy)dihydrocinnamate 
• 1441209-67-1 (S)-N-((8-isopropyl-6,7,9-trimethoxy-1-methyl-2,3,4,5-tetrahydro-1H-dibenzo[a,d][7]annulen-1-yl)methyl)-4-bromobenzamide 
• 866464-96-2 4-isopropyl-2,3,5-trimethoxybenzyl chloride 
• 156723-06-7 4-(1-methylethyl)-2,3,5-trimethoxyphenylmethyl alcohol 

Relevant academic research and scientific papers

Synthesis of (±)- and (+)-perovskone

A biomimetic synthesis of the triterpene (±)-perovskone was achieved featuring a remarkable polycyclization process in which three rings, four bonds, and five stereocenters were created in a single operation in 82% yield. This convergent synthesis required 16 steps, starting from vanillin, and proceeded in 9% overall yield. A second route to prepare optically active quinone 2 took 15 steps in 36% overall yield and featured a palladium-catalyzed reductive allylic transposition to establish the C-5 chirality stereospecifically. Quinone (-)-2 was converted to (+)-perovskone (1) via a polycyclization cascade, which created four rings, five bonds, and six stereocenters in a single operation in 50% yield.

Stereoselective syntheses of (±)-komaroviquinone and (±)-faveline methyl ether through intramolecular Heck reaction

An efficient, flexible, and stereoselective convergent route for constructing the trans-10-hydroxy-1,1-dimethyloctahydrodibenzo[a,d]cyclohepten- 7-ones (5a-c) was achieved via intramolecular Heck reaction. This strategy has been successfully implemented for the syntheses of (±)-komaroviquinone (3) through (±)-coulterone dimethyl ether (5c) and (±)-faveline methyl ether (1a).