Technology Process of 2-[6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
There total 6 articles about 2-[6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
[6-(4-chlorophenyl)-1-methyl-8-(methyloxy)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]acetic acid;
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
ethylamine;
In
tetrahydrofuran;
DOI:10.1021/jm200108t
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetic acid / tetrahydrofuran / 2 h / 20 °C
2: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C
3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C
With
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran;
DOI:10.1021/jm200108t
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Lawessons reagent / toluene / 4 h / Reflux
2.1: hydrazine hydrate / tetrahydrofuran / 5 h / 0 °C
2.2: 16 h / 0 - 20 °C
3.1: acetic acid / tetrahydrofuran / 2 h / 20 °C
4.1: sodium hydroxide / tetrahydrofuran / 5 h / 20 °C
5.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 3 h / 20 °C
With
Lawessons reagent; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
tetrahydrofuran; toluene;
DOI:10.1021/jm200108t