di-tert-butyl ((2S,2'S)-(((S)-ethyne-1,2-diylbis(3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(1-oxopropane-2,1-diyl))dicarbamate

Base Information

Chemical Name:di-tert-butyl ((2S,2'S)-(((S)-ethyne-1,2-diylbis(3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(1-oxopropane-2,1-diyl))dicarbamate
CAS No.:1597416-61-9
Molecular Formula:C₄₆H₆₆N₈O₁₀
Molecular Weight:891.078
Hs Code.:

di-tert-butyl ((2S,2'S)-(((S)-ethyne-1,2-diylbis(3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(1-oxopropane-2,1-diyl))dicarbamate

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Chemical Property of di-tert-butyl ((2S,2'S)-(((S)-ethyne-1,2-diylbis(3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(1-oxopropane-2,1-diyl))dicarbamate

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Technology Process of di-tert-butyl ((2S,2'S)-(((S)-ethyne-1,2-diylbis(3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(1-oxopropane-2,1-diyl))dicarbamate

There total 7 articles about di-tert-butyl ((2S,2'S)-(((S)-ethyne-1,2-diylbis(3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(1-oxopropane-2,1-diyl))dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613384-13-6
C₃₂H₃₈N₄O₁₀

: (S)-1-(isobutylamino)-1-oxopropan-2-aminium 2,2,2-trifluoroacetate

: 1597416-61-9
di-tert-butyl ((2S,2'S)-(((S)-ethyne-1,2-diylbis(3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(1-oxopropane-2,1-diyl))dicarbamate

Guidance literature:: With 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dicyclohexyl-carbodiimide; In tetrahydrofuran; at -10 - 20 ℃; for 16.25h; Inert atmosphere;
DOI:10.1002/anie.201309353

Reference yield:

: 283173-76-2
methyl 3-amino-2-iodobenzoate

: 1597416-61-9
di-tert-butyl ((2S,2'S)-(((S)-ethyne-1,2-diylbis(3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(1-oxopropane-2,1-diyl))dicarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dicyclohexyl-carbodiimide / tetrahydrofuran / 16.25 h / -10 - 60 °C / Inert atmosphere

2: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 60 °C / Inert atmosphere

3: sodium hydroxide; water / tetrahydrofuran / 1 h / Inert atmosphere

4: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dicyclohexyl-carbodiimide; 4-methyl-morpholine / tetrahydrofuran / 16.25 h / -10 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/anie.201309353

Reference yield:

: 1597416-57-3
(S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate

: 1597416-61-9
di-tert-butyl ((2S,2'S)-(((S)-ethyne-1,2-diylbis(3-(((S)-1-(isobutylamino)-1-oxopropan-2-yl)carbamoyl)-2,1-phenylene))bis(azanediyl))bis(1-oxopropane-2,1-diyl))dicarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 16 h / 60 °C / Inert atmosphere

2: sodium hydroxide; water / tetrahydrofuran / 1 h / Inert atmosphere

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dicyclohexyl-carbodiimide; 4-methyl-morpholine / tetrahydrofuran / 16.25 h / -10 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling;
DOI:10.1002/anie.201309353