283173-76-2Relevant academic research and scientific papers
Pd-catalyzed cascade cyclization by intramolecular heck insertion of an allene-allylic amination sequence: Application to the synthesis of 3,4-fused tricyclic indoles
Nakano, Shun-Ichi,Inoue, Naoya,Hamada, Yasumasa,Nemoto, Tetsuhiro
, p. 2622 - 2625 (2015)
A novel Pd-catalyzed cascade cyclization by intramolecular Heck insertion of an allene-allylic amination sequence was developed. Allenes tethered to ortho-iodoaniline derivatives at the meta-position were reacted with 5-10 mol % of Pd catalyst and 4 equiv
NOVEL COMPOUND, AND SYNTHESIS METHOD THEREFOR AND USE THEREOF
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Paragraph 0086-0087, (2017/07/31)
PROBLEM TO BE SOLVED: To provide: a method for synthesizing novel 3,4-position condensed ring type tricyclic indole derivatives or benzofurans; and a novel pharmaceutical composition. SOLUTION: The synthesis method is exemplified by the following preparat
Diphenylacetylene-linked peptide strands induce bidirectional β-sheet formation
Lingard, Hannah,Han, Jeongmin T.,Thompson, Amber L.,Leung, Ivanhoe K. H.,Scott, Richard T. W.,Thompson, Sam,Hamilton, Andrew D.
supporting information, p. 3650 - 3653 (2014/04/17)
In the search for synthetic mimics of protein secondary structures relevant to the mediation of protein-protein interactions, we have synthesized a series of tetrasubstituted diphenylacetylenes that display β-sheet structures in two directions. Extensive
BICYCLIC COMPOUND AND PHARMACEUTICAL USE THEREOF
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Page/Page column 104, (2010/01/29)
The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s); R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); Xa and Xb are each C, N, O or S; Xc and Xd are each C or N; m is 0-2; n is 1-3; ring A is a 5-membered ring optionally having substituent(s); ring B is a 6-membered ring optionally having substituent(s); and ring C is a 3- to 5-membered ring optionally having substituent(s), provided that when Xa, Xc and Xd are each C, then Xb is N or S, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.
