(S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate

Base Information

Chemical Name:(S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate
CAS No.:1597416-57-3
Molecular Formula:C₁₆H₂₁IN₂O₅
Molecular Weight:448.258
Hs Code.:

Synonyms:(S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate

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Chemical Property of (S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate

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Technology Process of (S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate

There total 2 articles about (S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 15761-38-3
L-N-Boc-Ala

: 283173-76-2
methyl 3-amino-2-iodobenzoate

: 1597416-57-3
(S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dicyclohexyl-carbodiimide; In tetrahydrofuran; at -10 - 60 ℃; for 16.25h; Inert atmosphere;
DOI:10.1002/anie.201309353

Reference yield:

: 93415-79-3
methyl 2-iodo-3-nitrobenzoate

: 1597416-57-3
(S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; iron(III) chloride / 2.5 h / 110 °C / Reflux; Inert atmosphere

2: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; dicyclohexyl-carbodiimide / tetrahydrofuran / 16.25 h / -10 - 60 °C / Inert atmosphere

With iron(III) chloride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; dicyclohexyl-carbodiimide; In tetrahydrofuran;
DOI:10.1002/anie.201309353

Reference yield: 89.0%

: 1597416-57-3
(S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-iodobenzoate

: 1597416-59-5
(S)-methyl 3-(2-((tert-butoxycarbonyl)amino)propanamido)-2-ethynylbenzoate

: 1597416-60-8
(S)-dimethyl 2,2'-(ethyne-1,2-diyl)bis(3-((S)-2-((tert-butoxycarbonyl)amino)propanamido)benzoate)

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 16h; Inert atmosphere;
DOI:10.1002/anie.201309353