hexahydro-endo,endo-6,9-diphenyl-5,7-methano-4H-cyclohepta-1,3-dioxole-2-thione

Base Information

Chemical Name:hexahydro-endo,endo-6,9-diphenyl-5,7-methano-4H-cyclohepta-1,3-dioxole-2-thione
CAS No.:83681-44-1
Molecular Formula:C₂₁H₂₀O₂S
Molecular Weight:336.455
Hs Code.:

hexahydro-endo,endo-6,9-diphenyl-5,7-methano-4H-cyclohepta<d>-1,3-dioxole-2-thione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of hexahydro-endo,endo-6,9-diphenyl-5,7-methano-4H-cyclohepta-1,3-dioxole-2-thione

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Technology Process of hexahydro-endo,endo-6,9-diphenyl-5,7-methano-4H-cyclohepta-1,3-dioxole-2-thione

There total 5 articles about hexahydro-endo,endo-6,9-diphenyl-5,7-methano-4H-cyclohepta-1,3-dioxole-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 83681-41-8,83709-52-8
endo,endo-7,8-diphenylbicyclo<4.1.1>octane-3,4-diol

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 83681-44-1,83729-99-1
hexahydro-endo,endo-6,9-diphenyl-5,7-methano-4H-cyclohepta-1,3-dioxole-2-thione

Guidance literature:: In benzene; for 20h; Heating;
DOI:10.1021/jo00148a008

Reference yield:

: 528-38-1
ε-truxillic acid

: 83681-44-1,83729-99-1
hexahydro-endo,endo-6,9-diphenyl-5,7-methano-4H-cyclohepta-1,3-dioxole-2-thione

Guidance literature:: Multi-step reaction with 5 steps

1: SOCl₂ / CHCl₃ / 1.) RT, 2 h, 2.) 50 deg C, 3 h

2: tetrahydrofuran; diethyl ether / 2 h / 0 °C

3: Et₃N, AgOAc / 50 °C

4: 1.) Na, K, Me₃SiCl, 2.) NaBH₄ / 1.) benzene, reflux, 4 h, 2.) EtOH, reflux, 2 h

5: 85 percent / benzene / 20 h / Heating

With sodium tetrahydroborate; chloro-trimethyl-silane; thionyl chloride; silver(I) acetate; sodium; triethylamine; In tetrahydrofuran; diethyl ether; chloroform; benzene;
DOI:10.1021/jo00148a008

Reference yield:

: 20324-70-3
ε-truxillic acid-dichloride

: 83681-44-1,83729-99-1
hexahydro-endo,endo-6,9-diphenyl-5,7-methano-4H-cyclohepta-1,3-dioxole-2-thione

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran; diethyl ether / 2 h / 0 °C

2: Et₃N, AgOAc / 50 °C

3: 1.) Na, K, Me₃SiCl, 2.) NaBH₄ / 1.) benzene, reflux, 4 h, 2.) EtOH, reflux, 2 h

4: 85 percent / benzene / 20 h / Heating

With sodium tetrahydroborate; chloro-trimethyl-silane; silver(I) acetate; sodium; triethylamine; In tetrahydrofuran; diethyl ether; benzene;
DOI:10.1021/jo00148a008