2,3-dibromo-1-fluoro-4-methoxybenzene

Base Information

• Chemical Name: 2,3-dibromo-1-fluoro-4-methoxybenzene
• CAS No.: 1266379-40-1
• Molecular Formula: C₇H₅Br₂FO
• Molecular Weight: 283.923
• Mol file: 1266379-40-1.mol

Synonyms:

Chemical Property of 2,3-dibromo-1-fluoro-4-methoxybenzene

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

2,3-Dibromo-4-fluoroanisole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-dibromo-1-fluoro-4-methoxybenzene

There total 2 articles about 2,3-dibromo-1-fluoro-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

2,3-dibromo-1,4-difluorobenzene (179737-33-8) + sodium methylate (124-41-4) → 2,3-dibromo-1-fluoro-4-methoxybenzene (1266379-40-1)

Guidance literature:

In methanol; dimethyl sulfoxide; for 5h; Inert atmosphere; Reflux;

DOI:10.1002/ejoc.201001217

Reference yield:

2-bromo-1,4-difluorobenzene (399-94-0) → 2,3-dibromo-1-fluoro-4-methoxybenzene (1266379-40-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

2.1: methanol; dimethyl sulfoxide / 5 h / Inert atmosphere; Reflux

With n-butyllithium; diisopropylamine; In tetrahydrofuran; methanol; hexane; dimethyl sulfoxide;

DOI:10.1002/ejoc.201001217

upstream raw materials:

2,3-dibromo-1,4-difluorobenzene

sodium methylate

2-bromo-1,4-difluorobenzene

Refernces