Methyl 2-(4-ethoxyphenyl)quinoline-4-carboxylate

Base Information

Chemical Name:Methyl 2-(4-ethoxyphenyl)quinoline-4-carboxylate
CAS No.:51842-73-0
Molecular Formula:C₁₉H₁₇NO₃
Molecular Weight:307.349
Hs Code.:
DSSTox Substance ID:DTXSID001239486

Synonyms:methyl 2-(4-ethoxyphenyl)quinoline-4-carboxylate;51842-73-0;CBMicro_046723;ChemDiv2_003972;Oprea1_138906;Oprea1_558465;DTXSID001239486;HMS1380E12;STK432651;AKOS001645687;IDI1_002687;BIM-0046735.P001;Methyl 2-(4-ethoxyphenyl)-4-quinolinecarboxylate;SR-01000484879;SR-01000484879-1

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 2-(4-ethoxyphenyl)quinoline-4-carboxylate

Chemical Property:

XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:307.12084340
Heavy Atom Count:23
Complexity:392

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC1=CC=C(C=C1)C2=NC3=CC=CC=C3C(=C2)C(=O)OC

Technology Process of Methyl 2-(4-ethoxyphenyl)quinoline-4-carboxylate

There total 6 articles about Methyl 2-(4-ethoxyphenyl)quinoline-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 67-56-1
methanol

: 54744-66-0
(2,3-dihydro-2-oxo-1H-indol-3-yl)acetonitrile

: 22237-13-4
(4-ethoxyphenyl)boronic acid

: 51842-73-0
methyl-2-(4-ethoxyphenyl)quinoline-4-carboxylate

Guidance literature:: With [2,2]bipyridinyl; palladium(II) trifluoroacetate; benzenesulfonic acid; at 80 ℃; for 24h; Schlenk technique; Sealed tube;
DOI:10.1021/acs.orglett.1c02962

Reference yield: 80.0%

: 67-56-1
methanol

: 51842-68-3
2-(4-ethoxyphenyl)quinoline-4-carboxylic acid

: 51842-73-0
methyl-2-(4-ethoxyphenyl)quinoline-4-carboxylate

Guidance literature:: With thionyl chloride; for 2h; Reflux;
DOI:10.1002/anie.201505054

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 51842-73-0
methyl-2-(4-ethoxyphenyl)quinoline-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 12 h / Reflux; Molecular sieve

2: thionyl chloride / 2 h / Reflux

With thionyl chloride; potassium hydroxide; In ethanol; 1: |Pfitzinger Quinoline Synthesis;
DOI:10.1002/anie.201505054