(3S)-3-tert-butyl-1-[(1S)-1-(p-methoxyphenyl)ethyl]-2,3-dihydro-1H-1,3-benzazaphosphole

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Chemical Name:(3S)-3-tert-butyl-1-[(1S)-1-(p-methoxyphenyl)ethyl]-2,3-dihydro-1H-1,3-benzazaphosphole
CAS No.:1542703-99-0
Molecular Formula:C₂₀H₂₆NOP
Molecular Weight:327.406
Hs Code.:

Synonyms:

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Chemical Property of (3S)-3-tert-butyl-1-[(1S)-1-(p-methoxyphenyl)ethyl]-2,3-dihydro-1H-1,3-benzazaphosphole

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Technology Process of (3S)-3-tert-butyl-1-[(1S)-1-(p-methoxyphenyl)ethyl]-2,3-dihydro-1H-1,3-benzazaphosphole

There total 19 articles about (3S)-3-tert-butyl-1-[(1S)-1-(p-methoxyphenyl)ethyl]-2,3-dihydro-1H-1,3-benzazaphosphole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1542703-63-8
2-[(S)-(1-(p-methoxyphenyl)ethyl)amino]benzenephosphonic acid diethyl ester

: 1542703-99-0,1542704-33-5
(3S)-3-tert-butyl-1-[(1S)-1-(p-methoxyphenyl)ethyl]-2,3-dihydro-1H-1,3-benzazaphosphole

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 72 h / -10 - 20 °C / Inert atmosphere; Schlenk technique

2.1: 120 h / 50 °C / Inert atmosphere; Schlenk technique

3.1: potassium tert-butylate / diethyl ether; hexane / 5 h / -70 - -30 °C / Inert atmosphere; Schlenk technique

3.2: 20 °C / Inert atmosphere; Schlenk technique

With lithium aluminium tetrahydride; potassium tert-butylate; In diethyl ether; hexane;
DOI:10.1021/om401184n

Reference yield:

: 1542703-73-0
N-[(S)-1-(p-methoxyphenyl)ethyl]-2-phosphinoaniline

: 1542703-99-0,1542704-33-5
(3S)-3-tert-butyl-1-[(1S)-1-(p-methoxyphenyl)ethyl]-2,3-dihydro-1H-1,3-benzazaphosphole

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane / 24 h / 50 °C / Inert atmosphere; Schlenk technique

2.1: potassium tert-butylate / diethyl ether; hexane / 5 h / -70 - -30 °C / Inert atmosphere; Schlenk technique

2.2: 20 °C / Inert atmosphere; Schlenk technique

With chloro-trimethyl-silane; potassium tert-butylate; In diethyl ether; hexane;
DOI:10.1021/om401184n

Reference yield:

: 583-53-9
2,3-dibromobenzene

: 1542703-99-0,1542704-33-5
(3S)-3-tert-butyl-1-[(1S)-1-(p-methoxyphenyl)ethyl]-2,3-dihydro-1H-1,3-benzazaphosphole

Guidance literature:: Multi-step reaction with 5 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium isobutoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 26 h / 80 - 100 °C / Inert atmosphere; Schlenk technique

2.1: palladium dichloride / 2 h / 180 - 190 °C / Inert atmosphere; Schlenk technique

3.1: lithium aluminium tetrahydride / diethyl ether / 72 h / -10 - 20 °C / Inert atmosphere; Schlenk technique

4.1: 120 h / 50 °C / Inert atmosphere; Schlenk technique

5.1: potassium tert-butylate / diethyl ether; hexane / 5 h / -70 - -30 °C / Inert atmosphere; Schlenk technique

5.2: 20 °C / Inert atmosphere; Schlenk technique

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium aluminium tetrahydride; potassium tert-butylate; sodium isobutoxide; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium dichloride; In diethyl ether; hexane; toluene; 1.1: |Buchwald-Hartwig Coupling;
DOI:10.1021/om401184n