Dodma

Base Information Edit

Chemical Name:Dodma
CAS No.:104162-47-2
Molecular Formula:C41H81NO2
Molecular Weight:620.08700
Hs Code.:
UNII:U587H2R5YR
Mol file:104162-47-2.mol

Synonyms:DODMA;104162-47-2;1,2-dioleyloxy-3-dimethylamino-propane;1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecenyloxy]-;1,2-dioleyloxy-3-(dimethylamino)propane;2,3-dioleyloxy-1-(dimethylamino)propane;N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine;starbld0000782;SCHEMBL26459;MBN-305A;U587H2R5YR;N,N-dimethyl-2,3-bis[(Z)-octadec-9-enoxy]propan-1-amine;GLGLUQVVDHRLQK-WRBBJXAJSA-N;EX-A5401;2,3-dioleyloxyl(dimethylamino)propane;1,2-Diloeyloxy-N,N-dimethylaminopropane;2,3-dioleyloxy-l-(dimethylamino)-propane;BP-25707;BS-45824;2,3-dioleyloxy-1-(dimethylamino)-propane;1,2-dioleyloxy-n,n-dimethyl-3-aminopropane;HY-112755;CS-0063325;E78336;N-[2,3-Di(oleyloxy)propyl]-N,N-dimethylamine;2,3-dioleyloxy-1- (N, N-dimethylamino) propane;2,3-Dioleyloxy-1-(dimethylamino)propane, >=98.0% (TLC);{2,3-BIS[(9Z)-OCTADEC-9-EN-1-YLOXY]PROPYL}DIMETHYLAMINE;1-Propanamine, N,N-dimethyl-2,3-bis(9-octadecenyloxy)-, (Z,Z)-;1-Propanamine, N,N-dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-;N,N-Dimethyl-2,3-bis[(9Z)-9-octadecen-1-yloxy]-1-propanamine;n-(2,3-di-(9-(z)-octadecenyloxy))prop-1-yl-n,n,-dimethylamine;N-(2,3-Di-(9-(Z)-octadecenyloxy))prop-1-yl-N,N-dimethylamine;N-(2,3-Di-(9-(Z)-octadecenyloxy))prop-l-yl-N,N,-dimethylamine

Suppliers and Price of Dodma

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
2,3-Dioleyloxy-1-(dimethylamino)propane ≥98.0% (TLC)
100mg
$ 136.00

Sigma-Aldrich
2,3-Dioleyloxy-1-(dimethylamino)propane ≥98.0% (TLC)
500mg
$ 538.00

Cayman Chemical
1,2-Dioleyloxy-3-dimethylamino-propane ≥98%
250mg
$ 206.00

Cayman Chemical
1,2-Dioleyloxy-3-dimethylamino-propane ≥98%
100mg
$ 99.00

Cayman Chemical
1,2-Dioleyloxy-3-dimethylamino-propane ≥98%
50mg
$ 55.00

Ambeed
N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine 98%
100mg
$ 128.00

Ambeed
N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine 98%
1g
$ 485.00

Ambeed
N,N-Dimethyl-2,3-bis((Z)-octadec-9-en-1-yloxy)propan-1-amine 98%
250mg
$ 193.00

AK Scientific
CID53844259
50mg
$ 174.00

Total 17 raw suppliers

Chemical Property of Dodma Edit

Chemical Property:

Boiling Point:649.7±55.0 °C(Predicted)
PKA:8.65±0.28(Predicted)
PSA：21.70000
Density:0.869±0.06 g/cm3(Predicted)
LogP:13.02480
Storage Temp.:?20°C
Solubility.:Soluble in Ethanol, DMSO, DMF
XLogP3:15.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:37
Exact Mass:619.62673083
Heavy Atom Count:44
Complexity:573

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Dioleyloxy-1-(dimethylamino)propane ≥98.0% (TLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCCCCCCCC=CCCCCCCCCOCC(CN(C)C)OCCCCCCCCC=CCCCCCCCC
Isomeric SMILES:CCCCCCCC/C=C\CCCCCCCCOCC(CN(C)C)OCCCCCCCC/C=C\CCCCCCCC
Description 1,2-Dioleyloxy-3-dimethylamino-propane (DODMA) is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of liposomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.
Uses 1,2-Dioleyloxy-3-dimethylamino-propane is a cationic lipid containing the unsaturated long-chain (18:1) oleic acid inserted at both the sn-1 and sn-2 positions. It has been used in the composition of lipospomes formulated as stable nucleic acid lipid particles that can encapsulate siRNA or other small molecules to be used for drug delivery.[Cayman Chemical] DODMA is responsible for the formation and morphology of lipid nanoparticles containing ionizable cationic lipids and siRNA useful for silencing disease-?causing genes in hepatocytes following i.v. administration.

Technology Process of Dodma

There total 5 articles about Dodma which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%