2,2-Difluoro-3-furan-3-yl-3-(4-methoxy-phenylamino)-propionic acid ethyl ester

Base Information

• Chemical Name: 2,2-Difluoro-3-furan-3-yl-3-(4-methoxy-phenylamino)-propionic acid ethyl ester
• CAS No.: 171251-88-0
• Molecular Formula: C₁₆H₁₇F₂NO₄
• Molecular Weight: 325.312
• Mol file: 171251-88-0.mol

Synonyms:

Chemical Property of 2,2-Difluoro-3-furan-3-yl-3-(4-methoxy-phenylamino)-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-Difluoro-3-furan-3-yl-3-(4-methoxy-phenylamino)-propionic acid ethyl ester

There total 2 articles about 2,2-Difluoro-3-furan-3-yl-3-(4-methoxy-phenylamino)-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-aniline (104-94-9) → 2,2-Difluoro-3-furan-3-yl-3-(4-methoxy-phenylamino)-propionic acid ethyl ester (171251-88-0)

Guidance literature:

Multi-step reaction with 4 steps

1: Na₂SO₄ / benzene / 0.5 h / Ambient temperature

2: zinc / tetrahydrofuran / 0.5 h / Heating

3: 1M aq. NaOH / tetrahydrofuran / 1 h

4: thionyl chloride / 15 h / 80 °C

With sodium hydroxide; thionyl chloride; sodium sulfate; zinc; In tetrahydrofuran; benzene;

DOI:10.1248/cpb.45.1793

Reference yield:

[1-Furan-3-yl-meth-(Z)-ylidene]-(4-methoxy-phenyl)-amine (1001909-35-8) → 2,2-Difluoro-3-furan-3-yl-3-(4-methoxy-phenylamino)-propionic acid ethyl ester (171251-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc / tetrahydrofuran / 0.5 h / Heating

2: 1M aq. NaOH / tetrahydrofuran / 1 h

3: thionyl chloride / 15 h / 80 °C

With sodium hydroxide; thionyl chloride; zinc; In tetrahydrofuran;

DOI:10.1248/cpb.45.1793

Reference yield:

2,2-Difluoro-3-furan-3-yl-3-(4-methoxy-phenylamino)-propionic acid ethyl ester (171251-88-0) → 13-O-[3-(tert-butoxycarbonylamino)-2,2-difluoro-3-(3-furyl)-propionyl]-10-deacetylbaccatin III

Guidance literature:

Multi-step reaction with 5 steps

1: CAN / acetonitrile; H₂O / 0.5 h / Ambient temperature

2: tetrahydrofuran / 18 h / 60 °C

3: 91 percent / LiOH / ethanol; H₂O / 0.5 h / Ambient temperature

4: 93 percent / DPC, 4-(dimethylamino)pyridine / toluene / 60 h / 80 °C

5: Zn, AcOH / methanol / 0.25 h / 60 °C

With dmap; lithium hydroxide; ammonium cerium(IV) nitrate; acetic acid; diphenylcyclopropenone; zinc; In tetrahydrofuran; methanol; ethanol; water; toluene; acetonitrile;

DOI:10.1248/cpb.45.1793

upstream raw materials:

4-methoxy-aniline

[1-Furan-3-yl-meth-(Z)-ylidene]-(4-methoxy-phenyl)-amine