(1-benzyl-1H-imidazol-2-yl)-phosphonous acid bis-diethylamide

Base Information

• Chemical Name: (1-benzyl-1H-imidazol-2-yl)-phosphonous acid bis-diethylamide
• CAS No.: 210903-90-5
• Molecular Formula: C₁₈H₂₉N₄P
• Molecular Weight: 332.429
• Mol file: 210903-90-5.mol

Synonyms:

Chemical Property of (1-benzyl-1H-imidazol-2-yl)-phosphonous acid bis-diethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1-benzyl-1H-imidazol-2-yl)-phosphonous acid bis-diethylamide

There total 3 articles about (1-benzyl-1H-imidazol-2-yl)-phosphonous acid bis-diethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzylimidazole (4238-71-5) + bis(diethylamino)chlorophosphine (685-83-6) → (1-benzyl-1H-imidazol-2-yl)-phosphonous acid bis-diethylamide (210903-90-5)

Guidance literature:

1-benzylimidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -80 ℃; for 0.5h; Inert atmosphere;

bis(diethylamino)chlorophosphine; In tetrahydrofuran; hexane; at -80 - 20 ℃; Inert atmosphere;

DOI:10.1007/s10593-011-0717-0

Reference yield:

1-benzylimidazole (4238-71-5) → (1-benzyl-1H-imidazol-2-yl)-phosphonous acid bis-diethylamide (210903-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1: PBr₃ / 24 h

With phosphorus tribromide; 1: phosphorylation / 2: Substitution;

DOI:10.1080/00397919808004288

Reference yield:

diethylamine (109-89-7) + C10H9Br2N2P → (1-benzyl-1H-imidazol-2-yl)-phosphonous acid bis-diethylamide (210903-90-5)

Guidance literature:

DOI:10.1080/00397919808004288

upstream raw materials:

diethylamine

1-benzylimidazole

bis(diethylamino)chlorophosphine

Downstream raw materials:

(1-benzyl-1H-imidazol-2-yl)phosphonic acid bis(diethylamide)