methyl N-benzoyl-2-methoxyglycinate

Base Information

• Chemical Name: methyl N-benzoyl-2-methoxyglycinate
• CAS No.: 21286-78-2
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.229
• Mol file: 21286-78-2.mol

Synonyms:

Chemical Property of methyl N-benzoyl-2-methoxyglycinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl N-benzoyl-2-methoxyglycinate

There total 11 articles about methyl N-benzoyl-2-methoxyglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

methanol (67-56-1) + α-hydroxyhippuric acid (19791-95-8,19791-97-0,16555-77-4) → methyl N-benzoyl-2-methoxyglycinate (21286-78-2,56538-58-0)

Guidance literature:

With sulfuric acid; at 0 - 20 ℃; for 48h;

Reference yield: 68.0%

methanol (67-56-1) + methyl hippurate (1205-08-9) → methyl N-benzoyl-2-methoxyglycinate (21286-78-2,56538-58-0) + α,α-dimethoxy-N-benzoyl-glycine methyl ester (125700-10-9)

Guidance literature:

sodium chloride; at 13 - 15 ℃; Product distribution; electrolysis; influence of the N-protecting group, the amino acid side-chain, and Cl^(1-) concentration at var. amino acid methyl esters;

DOI:10.1016/S0040-4020(01)80034-X

Reference yield:

N-benzoylserine methyl ester (20989-42-8) → methyl N-benzoyl-2-methoxyglycinate (21286-78-2,56538-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / I₂ / CH₂Cl₂ / 3 h / 26 °C / UV-irradiation

2: 207 mg / CH₂Cl₂ / 1 h

With iodine; In dichloromethane;

DOI:10.1021/jo071155t

upstream raw materials:

methanol

2-phenylazlactone

methyl hippurate

α-hydroxyhippuric acid

Downstream raw materials:

2-Benzamido-3,3,4-trimethyl-4-pentenoic acid

2-Benzoylamino-3,3,4-trimethyl-pent-4-enoic acid methyl ester

N-Benzoyl-β,β-dibenzoyl-alanin-methylester

methyl 2-benzamido-2-(diphenoxyphosphoryl)acetate