4-IODO-2-NITROPHENOL

Base Information

• Chemical Name: 4-IODO-2-NITROPHENOL
• CAS No.: 21784-73-6
• Molecular Formula: C6H4 I N O3
• Molecular Weight: 265.007
• Hs Code.: 2908999090
• Mol file: 21784-73-6.mol

Synonyms:4-Iodo-2-nitrophenol

Chemical Property of 4-IODO-2-NITROPHENOL

Chemical Property:

• Vapor Pressure: 0.000816mmHg at 25°C
• Boiling Point: 296.4°C at 760 mmHg
• Flash Point: 133°C
• PSA: 66.05000
• Density: 2.176g/cm³
• LogP: 2.42820
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98% ^*data from raw suppliers

4-Iodo-2-nitrophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-IODO-2-NITROPHENOL

There total 23 articles about 4-IODO-2-NITROPHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-(4-iodo-2-nitrophenoxy)pyridine → 4-iodo-2-nitrophenol (21784-73-6)

Guidance literature:

2-(4-iodo-2-nitrophenoxy)pyridine; With methyl trifluoromethanesulfonate; In toluene; at 90 ℃; for 2h; Inert atmosphere;

With sodium; In methanol; toluene; at 80 ℃; for 0.5h; Inert atmosphere;

Reference yield: 90.0%

2-hydroxynitrobenzene (88-75-5,78813-12-4) → 4-iodo-2-nitrophenol (21784-73-6) + 2-iodo-6-nitro-phenol (13073-26-2)

Guidance literature:

With Oxone; potassium iodide; In methanol; at 20 ℃; for 48h;

DOI:10.1081/SCC-120006002

Reference yield: 71.0%

tert.-butylnitrite (540-80-7) + p-Iodophenol (540-38-5) → 4-iodo-2-nitrophenol (21784-73-6)

Guidance literature:

With water; In tetrahydrofuran; at 25 ℃; for 2.5h; Schlenk technique;

DOI:10.1055/s-0036-1589038

upstream raw materials:

p-Iodophenol

roxarsone

4-Fluoro-3-nitroaniline

2-hydroxynitrobenzene

Downstream raw materials:

diiodo-4,6 nitro-2 phenol

2-amino-4-iodophenol

4-iodo-2,6-dinitrophenol

2,4,6-Trinitrophenol

Refernces

• 1、 Bartos, Paulina,Chrostowska, Anna,Hande, Aniket A.,Kaszyński, Piotr,Pietrzak, Anna. "Substituent effects on the electronic structure of the flat Blatter radical: Correlation analysis of experimental and computational data". supporting information. p. 22876 - 22887. Retrieved 2021/12/24.
• 2、 Juárez-Ornelas, Kevin A.,Jiménez-Halla, J. Oscar C.,Kato, Terumasa,Solorio-Alvarado, César R.,Maruoka, Keiji. "Iodine(III)-Catalyzed Electrophilic Nitration of Phenols via Non-Br?nsted Acidic NO2+ Generation". supporting information. p. 1315 - 1319. Retrieved 2019/03/07.