Technology Process of C19H25F2NO3
There total 10 articles about C19H25F2NO3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 10 steps
1: sodium hydride / tetrahydrofuran / 20 °C
2: palladium 10% on activated carbon; hydrogen / ethanol
3: water; potassium hydroxide / ethanol / 20 °C
4: triethylamine / diethyl ether / 20 °C
5: n-butyllithium / tetrahydrofuran / -78 °C
6: sodium hexamethyldisilazane / tetrahydrofuran / -78 °C
7: dihydrogen peroxide; lithium hydroxide / tetrahydrofuran; water / 20 °C
8: hydrogenchloride / tetrahydrofuran; water / 20 °C
9: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / toluene / 110 °C
10: chloro-trimethyl-silane / dichloromethane / 20 °C
With
hydrogenchloride; n-butyllithium; chloro-trimethyl-silane; diphenyl phosphoryl azide; palladium 10% on activated carbon; water; hydrogen; dihydrogen peroxide; sodium hexamethyldisilazane; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; lithium hydroxide;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; toluene;
9: Curtius rearrangement;
DOI:10.1016/j.bmcl.2010.12.060
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogenchloride / tetrahydrofuran; water / 20 °C
2: diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine / toluene / 110 °C
3: chloro-trimethyl-silane / dichloromethane / 20 °C
With
hydrogenchloride; chloro-trimethyl-silane; diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; water; toluene;
2: Curtius rearrangement;
DOI:10.1016/j.bmcl.2010.12.060