Azido-PEG12-NHS ester

Base Information

Chemical Name:Azido-PEG12-NHS ester
CAS No.:1610796-02-5
Molecular Formula:C₁₃H₂₀N₄O₇
Molecular Weight:344.324
Hs Code.:
Mol file:1610796-02-5.mol

Synonyms:

Suppliers and Price of Azido-PEG12-NHS ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Apolloscientific
Azido-PEG12-NHS ester
100mg
$ 740.00

Total 8 raw suppliers

Chemical Property of Azido-PEG12-NHS ester

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Azido-PEG12-NHS ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Azido-PEG12-NHS ester ester series of products contain an azide function on one end of a single molecular weight dPEG? spacer and a reactive group on the other end of the spacer. The dPEG? spacer is hydrophilic and non-immunogenic and improves the water solubility of the target molecule while reducing the immunogenicity and increasing the hydrodynamic volume of the target.

Technology Process of Azido-PEG12-NHS ester

There total 12 articles about Azido-PEG12-NHS ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 1056024-94-2
3-{2-[2-(2-azidoethoxy)-ethoxy]ethoxy}propanoic acid

: 1610796-02-5
2,5-dioxopyrrolidin-1-yl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 8h;

Reference yield: 82.0%

: 6066-82-6
1-hydroxy-pyrrolidine-2,5-dione

: 1312309-63-9
3-(2-(2-azidoethoxy)ethoxy)propanoic acid

: 1610796-02-5
2,5-dioxopyrrolidin-1-yl-3 (2-(2-azidoethoxy)ethoxy)propanoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 8h;

Reference yield:

: 133803-81-3,892154-71-1
2-methyl-2-propanyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate

: 1610796-02-5
2,5-dioxopyrrolidin-1-yl-3 (2-(2-azidoethoxy)ethoxy)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / dichloromethane / 5.5 h

2: sodium azide / N,N-dimethyl acetamide / 4 h / 80 °C

3: hydrogenchloride / 1,4-dioxane; water / 0.58 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 8 h

With pyridine; hydrogenchloride; sodium azide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water;