4-{[(4-methylphenyl)sulfonyl]amino}benzoyl chloride

Base Information

• Chemical Name: 4-{[(4-methylphenyl)sulfonyl]amino}benzoyl chloride
• CAS No.: 37028-89-0
• Molecular Formula: C14H12 Cl N O3 S
• Molecular Weight: 309.773
• Mol file: 37028-89-0.mol

Synonyms:NSC 211023

Chemical Property of 4-{[(4-methylphenyl)sulfonyl]amino}benzoyl chloride

Chemical Property:

• Vapor Pressure: 1.28E-08mmHg at 25°C
• Boiling Point: 459.3°C at 760 mmHg
• Flash Point: 231.6°C
• Density: 1.4g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-{[(4-methylphenyl)sulfonyl]amino}benzoyl chloride

There total 7 articles about 4-{[(4-methylphenyl)sulfonyl]amino}benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

N-tosyl-4-iodoaniline (158268-30-5) + 4-nitro-benzoyl chloride (122-04-3) → p-nitrobenzene iodide (636-98-6) + 4-(toluene-4-sulfonylamino)-benzoyl chloride (37028-89-0)

Guidance literature:

With (Xantphos)Pd(4-C₆H₄NO₂)(I); In benzene; at 90 ℃; for 20h; Sealed tube; Inert atmosphere;

DOI:10.1021/jacs.8b06605

Reference yield:

N-tosyl-4-iodoaniline (158268-30-5) + terephthaloyl chloride (100-20-9) → 4-(toluene-4-sulfonylamino)-benzoyl chloride (37028-89-0) + 4-iodobenzoic acid chloride (1711-02-0)

Guidance literature:

With (Xantphos)Pd(4-C₆H₄NO₂)(I); In benzene; at 90 ℃; for 20h; Sealed tube; Inert atmosphere;

DOI:10.1021/jacs.8b06605

Reference yield:

4-[(4-methylphenyl)sulfonamido]benzoic acid (37028-85-6) → 4-(toluene-4-sulfonylamino)-benzoyl chloride (37028-89-0)

Guidance literature:

With pyridine; thionyl chloride; benzene;

DOI:10.1021/ja01111a006

upstream raw materials:

4-[(4-methylphenyl)sulfonamido]benzoic acid

4-methoxycarbonyl aniline

methyl 4-{[(4-methylphenyl)sulfonyl]amino}benzoate

p-toluenesulfonyl chloride

Downstream raw materials:

2-n-butyl-3-[N-(4-methyl-benzenesulfonyl)-4-aminobenzoyl]-benzofuran

4-p-Toluolsulfonylamino-benzoesaeure-<2.3-dimercapto-propylester>

N-[4-(toluene-4-sulfonylamino)-benzoyl]-L-glutamic acid diethyl ester

Refernces

• 1、 Zhang, Jiankang,Shen, Luqing,Wang, Jincheng,Luo, Peihua,Hu, Yongzhou. "Design, synthesis and biological evaluation of novel non-peptide boronic acid derivatives as proteasome inhibitors". . p. 38 - 45. Retrieved 2014/01/17.