ES-3'-C₈-dG

Base Information

• Chemical Name: ES-3'-C₈-dG
• CAS No.: 1282040-43-0
• Molecular Formula: C₂₀H₂₃N₅O₅
• Molecular Weight: 413.433
• Mol file: 1282040-43-0.mol

Synonyms:

Chemical Property of ES-3'-C₈-dG

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ES-3'-C₈-dG

There total 2 articles about ES-3'-C₈-dG which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.2%

1'-acetoxyestragole (61691-82-5) + 2'-Deoxyguanosine (961-07-9) → ES-3'-N2-dG (1282040-44-1) + ES-3'-C8-dG (1282040-43-0)

Guidance literature:

In dichloromethane; N,N-dimethyl-formamide; at 50 ℃; for 24h; pH=7.4; aq. phosphate buffer;

DOI:10.1021/tx100410y

Reference yield:

4-methoxy-benzaldehyde (123-11-5) → ES-3'-N2-dG (1282040-44-1) + ES-3'-C8-dG (1282040-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 2 h / 50 °C / Inert atmosphere

2: pyridine / 5 h / 20 °C

3: dichloromethane; N,N-dimethyl-formamide / 24 h / 50 °C / pH 7.4 / aq. phosphate buffer

With pyridine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/tx100410y

upstream raw materials:

1'-acetoxyestragole

2'-Deoxyguanosine

4-methoxy-benzaldehyde