[1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1H-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1H-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester
CAS No.:811795-90-1
Molecular Formula:C₃₇H₅₀N₆O₆
Molecular Weight:674.841
Hs Code.:

[1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1<i>H</i>-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid <i>tert</i>-butyl ester

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Chemical Property of [1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1H-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

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Technology Process of [1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1H-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

There total 10 articles about [1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1H-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14062-18-1
ethyl p-methoxyphenylacetate

: 811795-90-1
[1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1H-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: N-bromosuccinimide; AIBN

2: K₂CO₃

3: 92 percent / sodium bis(trimethylsilyl)amide

4: LiOH

5: oxalyl chloride

6: n-BuLi

7: LiOH

8: oxalyl chloride

9: H₂ / Pd/C

10: DCC; HOBt

With lithium hydroxide; N-Bromosuccinimide; n-butyllithium; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydrogen; sodium hexamethyldisilazane; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal;
DOI:10.1016/j.bmcl.2004.09.027

Reference yield:

: 77629-83-5,77053-56-6
ethyl 2-bromo-2-(4-methoxyphenyl) acetate

: 811795-90-1
[1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1H-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: K₂CO₃

2: 92 percent / sodium bis(trimethylsilyl)amide

3: LiOH

4: oxalyl chloride

5: n-BuLi

6: LiOH

7: oxalyl chloride

8: H₂ / Pd/C

9: DCC; HOBt

With lithium hydroxide; n-butyllithium; oxalyl dichloride; hydrogen; sodium hexamethyldisilazane; potassium carbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal;
DOI:10.1016/j.bmcl.2004.09.027

Reference yield:

: (R)-2-(4-Methoxy-phenyl)-2-(4-nitro-imidazol-1-yl)-propionyl chloride

: 811795-90-1
[1-(1-{1-[1-(4-methoxy-phenyl)-1-methyl-2-oxo-2-pyrrolidin-1-yl-ethyl]-1H-imidazol-4-ylcarbamoyl}-4-phenyl-butylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: DCC; HOBt

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal;
DOI:10.1016/j.bmcl.2004.09.027