2-Amino-1-(4-methoxyphenyl)ethanol

Base Information

• Chemical Name: 2-Amino-1-(4-methoxyphenyl)ethanol
• CAS No.: 55275-61-1
• Molecular Formula: C9H13 N O2
• Molecular Weight: 167.208
• Hs Code.: 2922509090
• European Community (EC) Number: 259-561-7
• DSSTox Substance ID: DTXSID90902584
• Nikkaji Number: J90.257H
• ChEMBL ID: CHEMBL4556890
• Mol file: 55275-61-1.mol

Synonyms:2-amino-1-(4-methoxyphenyl)ethanol;55275-61-1;alpha-(Aminomethyl)-4-methoxybenzyl alcohol;EINECS 259-561-7;2-amino-1-(4-methoxyphenyl)ethan-1-ol;alpha-(Aminomethyl)-p-anisyl Alcohol;46084-19-9;2-Amino-1-(4-methoxy-phenyl)-ethanol;Benzenemethanol,a-(aminomethyl)-4-methoxy-,(S)-;Benzenemethanol, a-(aminomethyl)-4-methoxy-, (S)-;NoName_3107;SCHEMBL336019;CHEMBL4556890;4-Methoxy-ss-hydroxyphenethylamin;DTXSID90902584;LQEPONWCAMNCOY-UHFFFAOYSA-N;AMY13702;1-(4-Methoxyphenyl)-2-aminoethanol;AKOS000123288;AKOS016053310;2-hydroxy-2-(4-methoxyphenyl)ethylamine;BS-28671;CS-0453719;EN300-36912;C78301;2-Amino-1-(4-methoxyphenyl)ethanol, AldrichCPR

Chemical Property of 2-Amino-1-(4-methoxyphenyl)ethanol

Chemical Property:

• Vapor Pressure: 9.43E-05mmHg at 25°C
• Melting Point: 70℃
• Boiling Point: 325.4°C at 760 mmHg
• Flash Point: 150.6°C
• PSA: 55.48000
• Density: 1.128±0.06 g/cm3 (20 ºC 760 Torr)
• LogP: 1.38760
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 167.094628657
• Heavy Atom Count: 12
• Complexity: 122

Purity/Quality:

99% ^*data from raw suppliers

α-(Aminomethyl)-p-anisylAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(CN)O
• Uses: α-(Aminomethyl)-p-anisyl Alcohol, can be used for the synthesis of various pharmaceutical compounds. It can be used for the preparation of derivatives of marine alkaloid tsitsikammamine A, having inhibitory activity. It is also an intermediate for the synthesis of Aegeline (A325500).

Technology Process of 2-Amino-1-(4-methoxyphenyl)ethanol

There total 35 articles about 2-Amino-1-(4-methoxyphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

β-azido-α-(4-methoxyphenyl)ethanol (144924-01-6) → 2-amino-1-(4-methoxyphenyl)ethanol (55275-61-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 30 ℃; for 2h; under 7500.75 Torr; Green chemistry;

DOI:10.1039/c3gc41666f

Reference yield: 94.0%

C19H17N3O2 (291301-32-1) → 2-amino-1-(4-methoxyphenyl)ethanol (55275-61-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 24h;

DOI:10.1016/S0040-4039(00)00689-4

Reference yield: 90.0%

2-(2-hydroxy-2-(4-methoxy-phenyl)-ethyl)-isoindole-1,3-dione (100423-00-5) → 2-amino-1-(4-methoxyphenyl)ethanol (55275-61-1)

Guidance literature:

With hydrazine hydrate; In water; at 60 ℃; for 3h;

DOI:10.1080/00397911.2011.603876

upstream raw materials:

4-methoxymandelonitrile

p-methoxy-isonitrosoacetophenone

4-methoxybenzoyl cyanide

nitromethane

Downstream raw materials:

5-(4-methoxy-phenyl)-oxazolidine-2-thione

3-phenyl-propionic acid-(4-methoxy-phenacylamide)

C₂₃H₃₉NO₃

N-dichloroacetyl-5-(p-methoxyphenyl)-2,2-dimethyl-1,3-oxazolidine