Cholest-4-ene-3,6-dione

Base Information

• Chemical Name: Cholest-4-ene-3,6-dione
• CAS No.: 54339-68-3
• Molecular Formula: C₂₇H₄₂O₂
• Molecular Weight: 398.629
• Mol file: 54339-68-3.mol

Synonyms:

Chemical Property of Cholest-4-ene-3,6-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cholest-4-ene-3,6-dione

There total 20 articles about Cholest-4-ene-3,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

cholesterol (57-88-5) → Cholest-4-en-3-one (601-57-0) + 4-cholestene-3,6-dione (54339-68-3,984-84-9) + cholest-4-ene-6β-hydroperoxy-3-one (2207-76-3) + 6α-hydroxy-cholest-4-en-3-one (570-90-1)

Guidance literature:

With cholesterol oxidase; In isopropyl alcohol; at 37 ℃; for 24h; Further byproducts given. Yields of byproduct given;

DOI:10.1021/ja962258o

Reference yield: 98.0%

Cholest-5-en-3-one (601-54-7) → Cholest-4-en-3-one (601-57-0) + 4-cholestene-3,6-dione (54339-68-3,984-84-9) + cholest-4-ene-6β-hydroperoxy-3-one (2207-76-3) + 6α-hydroxy-cholest-4-en-3-one (570-90-1)

Guidance literature:

With cholesterol oxidase; In isopropyl alcohol; at 37 ℃; for 24h; Further byproducts given. Yields of byproduct given;

DOI:10.1021/ja962258o

Reference yield: 62.0%

4β-hydroxycholesterol (17320-10-4) → Cholest-4-en-3-one (601-57-0) + 4-cholestene-3,6-dione (54339-68-3,984-84-9) + 5α-cholestane-3,6-dione (2243-09-6)

Guidance literature:

With p-toluenesulfonic acid on sillica gel; at 120 ℃; for 0.166667h; Reagent/catalyst; Inert atmosphere; Green chemistry;

DOI:10.1039/c7nj01878a

upstream raw materials:

cholesterol

Cholest-5-en-3-one

Cholest-4-en-3-one

5α,6α-epoxycholestan-3β-ol

Downstream raw materials:

acide de Butenandt

cholestane

C₃₃H₄₄F₄N₂O

C₃₃H₄₇N₃O₃

Refernces

• 1、 Offei, Samuel D.,Arman, Hadi D.,Yoshimoto, Francis K.. "Chemical synthesis of 7α-hydroxycholest-4-en-3-one, a biomarker for irritable bowel syndrome and bile acid malabsorption". . . Retrieved 2019/07/31.
• 2、 Ghosh, Pranab,Ghosh, Ashim,Mandal, Amitava,Sultana, Sirin Salma,Dey, Somaditya,Pal, Chiranjib. "Oxysterols: Synthesis and anti-leishmanial activities". . p. 65 - 73. Retrieved 2016/03/04.