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17320-10-4

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17320-10-4 Usage

Chemical Properties

White Solid

Uses

Different sources of media describe the Uses of 17320-10-4 differently. You can refer to the following data:
1. A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.
2. A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential

Definition

ChEBI: A oxysterol that is cholesterol in which the hydrogen at the 4beta position has been replaced by a hydroxy group. A metabolite of cholesterol formed by the drug-metabolizing enzyme cytochrome P450 3A4, it is one of the major oxysterols in he human circulation.

Biological Activity

4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].cytochome p450 3a4 (cyp3a4) and cyp3a5 are important drug-metabolizing enzymes that oxidize small foreign organic molecules, such as toxins or drugs, and remove them from the body. they exhibit a large variation in hepatic expression and biological activity between different individuals. patients treated with drugs known to be strong inducers of cyp3a4/5 have highly elevated levels of 4β-hydroxycholesterol in the circulation [1].4β-hydroxy cholesterol, an endogenous oxysterol found in human circulation, is formed from cholesterol by cytochrome p450 (cyp) 3a4 and cyp3a5. in 12 different occasions during a 3-month period, the cvs for 4β-hydroxycholesterol ranged from 4.8 to 13.2% with an average cv of 7.1% at an average concentration of 30.8 ng/ml. in 24 volunteers treated with rifampicin, a strong cyp3a4/5 inducer, 4β-hydroxycholesterol increased in a dose-dependent way, while the isomer 4α-hydroycholesterol was not influenced by rifampicin treatment. these results suggested that 4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].

references

[1]. diczfalusy u, kanebratt kp, bredberg e, et al. 4beta-hydroxycholesterol as an endogenous marker for cyp3a4/5 activity. stability and half-life of elimination after induction with rifampicin. br j clin pharmacol. 2009 jan;67(1):38-43.

Check Digit Verification of cas no

The CAS Registry Mumber 17320-10-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,3,2 and 0 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 17320-10:
(7*1)+(6*7)+(5*3)+(4*2)+(3*0)+(2*1)+(1*0)=74
74 % 10 = 4
So 17320-10-4 is a valid CAS Registry Number.
InChI:InChI=1/C27H46O2/c1-17(2)7-6-8-18(3)20-11-12-21-19-9-10-23-25(29)24(28)14-16-27(23,5)22(19)13-15-26(20,21)4/h10,17-22,24-25,28-29H,6-9,11-16H2,1-5H3

17320-10-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 4β-hydroxycholesterol

1.2 Other means of identification

Product number -
Other names 4-β-HYDROXYCHOLESTEROL

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:17320-10-4 SDS

17320-10-4Relevant articles and documents

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Dahl,T.,Stevenson,R.

, p. 3243 - 3246 (1971)

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Cholesterol transformations during heat treatment

Derewiaka,Molińska

, p. 233 - 240 (2015/01/09)

The aim of the study was to characterise products of cholesterol standard changes during thermal processing. Cholesterol was heated at 120 °C, 150 °C, 180 °C and 220 °C from 30 to 180 min. The highest losses of cholesterol content were found during thermal processing at 220 °C, whereas the highest content of cholesterol oxidation products was observed at temperature of 150 °C. The production of volatile compounds was stimulated by the increase of temperature. Treatment of cholesterol at higher temperatures i.e. 180 °C and 220 °C led to the formation of polymers and other products e.g. cholestadienes and fragmented cholesterol molecules. Further studies are required to identify the structure of cholesterol oligomers and to establish volatile compounds, which are markers of cholesterol transformations, mainly oxidation.

Synthesis of [D4]- and [D7]-4β- hydroxycholesterols for use in a novel drug-drug interaction assay

Turley, Wesley A.,Burrell, Richard C.,Bonacorsi Jr., Samuel J.,Goodenough, Angela K.,Onorato, Joelle M.

scheme or table, p. 61 - 65 (2012/06/30)

Cytochrome P450 3A (CYP3A) enzymes are involved in the metabolism of over half of today's prescription drugs. As a result, drugs metabolized by CYP3A have a risk of drug-drug interactions (DDIs). Recent studies have shown the potential to use 4β-hydroxych

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