3,3-Dimethyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinolinium iodide

Base Information

Chemical Name:3,3-Dimethyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinolinium iodide
CAS No.:129959-24-6
Molecular Formula:C₁₈H₂₀NO*I
Molecular Weight:393.267
Hs Code.:

Synonyms:

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Chemical Property of 3,3-Dimethyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinolinium iodide

Chemical Property:

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Technology Process of 3,3-Dimethyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinolinium iodide

There total 11 articles about 3,3-Dimethyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinolinium iodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 129959-23-5
3-Methyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinoline

: 74-88-4
methyl iodide

: 129959-24-6
3,3-Dimethyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinolinium iodide

Guidance literature:: In acetonitrile; for 2h; Heating;
DOI:10.1002/ardp.19903230603

Reference yield:

: 1723-70-2
8-methoxyisoquinoline

: 129959-24-6
3,3-Dimethyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinolinium iodide

Guidance literature:: Multi-step reaction with 10 steps

1: 84 percent / H₂O₂ (30percent) / acetic acid / 60 - 70 °C

2: 1) acetic anhydride, 2) NaOH / 1) reflux, 5 h, 2) H₂O, 80-90 deg C, 1 h

3: 78 percent / POCl₃ / 0.5 h / Heating

4: 1) n-C₄H₉Li / THF, hexane, 1) -80 deg C, 1 h, 2) -70 to -80 deg C, 6 h and warm to RT, overnight

5: 93 percent / HgO, BF₃*Et₂O / tetrahydrofuran; H₂O

6: 92 percent / acetone / 4 h / Heating

7: 11 percent / NaBH₄ / methanol / 1 h / Heating

8: 70 percent / BBr₃ / CH₂Cl₂ / 15 h / Ambient temperature

9: 77 percent / CF₃COOH / 3 h / 70 - 75 °C

10: 95 percent / acetonitrile / 2 h / Heating

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; dihydrogen peroxide; acetic anhydride; boron tribromide; trifluoroacetic acid; mercury(II) oxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid; acetone; acetonitrile;
DOI:10.1002/ardp.19903230603

Reference yield:

: 1010-75-9
8-Methoxyisoquinoline-N-oxide

: 129959-24-6
3,3-Dimethyl-2a,3,4,5-tetrahydro-2H-furo<2,3,4-i,k>isoquinolinium iodide

Guidance literature:: Multi-step reaction with 9 steps

1: 1) acetic anhydride, 2) NaOH / 1) reflux, 5 h, 2) H₂O, 80-90 deg C, 1 h

2: 78 percent / POCl₃ / 0.5 h / Heating

3: 1) n-C₄H₉Li / THF, hexane, 1) -80 deg C, 1 h, 2) -70 to -80 deg C, 6 h and warm to RT, overnight

4: 93 percent / HgO, BF₃*Et₂O / tetrahydrofuran; H₂O

5: 92 percent / acetone / 4 h / Heating

6: 11 percent / NaBH₄ / methanol / 1 h / Heating

7: 70 percent / BBr₃ / CH₂Cl₂ / 15 h / Ambient temperature

8: 77 percent / CF₃COOH / 3 h / 70 - 75 °C

9: 95 percent / acetonitrile / 2 h / Heating

With sodium hydroxide; sodium tetrahydroborate; n-butyllithium; boron trifluoride diethyl etherate; acetic anhydride; boron tribromide; trifluoroacetic acid; mercury(II) oxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1002/ardp.19903230603