((1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]hept-2-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

Base Information

• Chemical Name: ((1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]hept-2-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone
• CAS No.: 446872-99-7
• Molecular Formula: C₂₄H₃₂N₂O₃S
• Molecular Weight: 428.596

Synonyms:

Chemical Property of ((1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]hept-2-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]hept-2-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone

There total 2 articles about ((1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]hept-2-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ⁶-thia-4-aza-tricyclo[5.2.1.0^1,5]dec-4-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → ((1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]hept-2-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (446872-99-7)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetonitrile

2: AgF / CH₂Cl₂ / 6 h

With silver fluoride; potassium carbonate; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4020(02)00322-8

Reference yield:

acrylcamphorsultam (94594-91-9) + 2,5-bis(trimethylsilyl)-N-benzylpyrrolidine (154344-51-1) → ((1R,2R,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]hept-2-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone + ((1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]hept-2-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (446872-99-7)

Guidance literature:

With silver fluoride; In dichloromethane; for 6h;

DOI:10.1016/S0040-4020(02)00322-8

Reference yield:

((1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]hept-2-yl)-((1S,5R,7R)-10,10-dimethyl-3,3-dioxo-3λ6-thia-4-aza-tricyclo[5.2.1.01,5]dec-4-yl)-methanone (446872-99-7) → (1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]heptane-2-carboxylic acid (446873-05-8)

Guidance literature:

With lithium hydroxide; In methanol; at 45 ℃; for 0.75h;

DOI:10.1016/S0040-4020(02)00322-8

upstream raw materials:

acrylcamphorsultam

2,5-bis(trimethylsilyl)-N-benzylpyrrolidine

benzyl bromide

Downstream raw materials:

(1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]heptane-2-carboxylic acid

(1R,2S,4S)-7-Benzyl-7-aza-bicyclo[2.2.1]heptane-2-carboxylic acid methyl ester

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