o-phenyl ethyl ketone

Base Information

• Chemical Name: o-phenyl ethyl ketone
• CAS No.: 154010-82-9
• Molecular Formula: C₂₉H₂₈NO₂P
• Molecular Weight: 453.521
• Mol file: 154010-82-9.mol

Synonyms:

Chemical Property of o-phenyl ethyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of o-phenyl ethyl ketone

There total 2 articles about o-phenyl ethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(benzylamino)benzonitrile (5589-62-8) → o-phenyl ethyl ketone (154010-82-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) HCl / 1.) Et₂O, 0 deg C, 5 h, 2.) H₂O, room temperature, 0.5 h

2: 1.) EtOH, 3.) K₂CO₃ / 1.) toluene, reflux, overnight, 2.) THF, room temperature, 1 h, 3.) 15 min

With hydrogenchloride; ethanol; potassium carbonate;

DOI:10.1039/P19930002463

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + chloro-diphenylphosphine (1079-66-9,74391-44-9) + 1-[2-(benzylamino)phenyl]propan-1-one (154010-87-4) → o-phenyl ethyl ketone (154010-82-9)

Guidance literature:

With ethanol; potassium carbonate; Yield given. Multistep reaction; 1.) toluene, reflux, overnight, 2.) THF, room temperature, 1 h, 3.) 15 min;

DOI:10.1039/P19930002463

Reference yield: 68.0%

o-phenyl ethyl ketone (154010-82-9) → 1-benzyl-2-diphenylphosphinoyl-3-ethylindole

Guidance literature:

With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; 1.) 0 deg C, 1 h, 2.) -78 deg C, 0.5 h;

DOI:10.1039/P19930002463

upstream raw materials:

formaldehyd

chloro-diphenylphosphine

1-[2-(benzylamino)phenyl]propan-1-one

2-(benzylamino)benzonitrile

Downstream raw materials:

1-benzyl-3-ethyl-1H-indole