trans-2-acetylthiocyclopentanol

Base Information

• Chemical Name: trans-2-acetylthiocyclopentanol
• CAS No.: 116154-88-2
• Molecular Formula: C₇H₁₂O₂S
• Molecular Weight: 160.237
• Mol file: 116154-88-2.mol

Synonyms:

Chemical Property of trans-2-acetylthiocyclopentanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-2-acetylthiocyclopentanol

There total 4 articles about trans-2-acetylthiocyclopentanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Cyclopentene oxide (285-67-6) + tiolacetic acid (507-09-5) → trans-2-acetylthiocyclopentanol (3551-50-6,116154-88-2)

Guidance literature:

at 20 ℃; for 168h;

DOI:10.1016/S0040-4039(02)01750-1

Reference yield:

cyclopentene (142-29-0) → trans-2-acetylthiocyclopentanol (3551-50-6,116154-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: water; N-bromo-succinimide / Behandeln des Reaktionsprodukts mit wss. Natronlauge

With N-Bromosuccinimide; water;

DOI:10.1021/ja01540a044

Reference yield:

cyclohexene oxide (286-20-4) + tiolacetic acid (507-09-5) → S-(1R,2R)-2-mercaptocyclopentyl acetate (3551-50-6,116154-88-2) + S-(1S,2S)-2-mercaptocyclopentyl acetate

Guidance literature:

With C₅₆H₆₁O₄P; In toluene; at -10 ℃; Overall yield = 63 %;

DOI:10.1021/ja510069w

upstream raw materials:

cyclohexene oxide

tiolacetic acid

Cyclopentene oxide

thioacetic acid